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OpenTrials
Active, Not Recruiting

NCT Number: NCT03523377

Overnight Fasting After Completion of Therapy: The OnFACT Study

The purpose of this study is to test whether regularly not eating for at least 14 hours overnight ("intermittent fasting") is feasible and can improve blood sugar.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Childhood Cancer Survivors Behavior Fasting Feeding Behavior

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Memorial Sloan Kettering Cancer Center

New York, 10065, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Body mass index is ≥ 18.5 kg/m^2
  • History of treatment for cancer or related illness diagnosed at ≤ 25 years old
  • Off cytotoxic therapy for primary cancer ≥ 2 years
  • Not receiving cytotoxic therapy (chemotherapy, external beam radiation therapy) at the time of study enrollment
  • History of radiation to the chest, abdomen or total body
  • Current age ≥18 years
  • English-speaking
  • Personal phone with SMS text messaging capability
  • Willingness to wear an mHealth device, such as a FitBit, for two 7-day periods
  • Able to perform all study requirements

Exclusion criteria

  • Use of any antidiabetic, weight loss, or appetite control medication
  • Use of any other medication that could impact dietary intake, such as prednisone
  • Currently fasts 12 hours or more by self-report
  • Unable to fast due to medical reason such as pregnancy

Treatment and study plan

prolonged overnight fasting

Other

Three phone calls using motivational interviewing, support via SMS text.

Usual Care

Other

Eat a heart-healthy diet and exercise for at least 30 minutes five days a week

Primary outcomes

  1. Participation completion

    Time frame: 6 months

    Proportion of registered participants who successfully complete the 6-month intervention

Secondary outcomes

  1. measure of glucose metabolism

    Time frame: 6 months

    Assess the effect of prolonged overnight fasting on glucose metabolism, measured by glycosylated hemoglobin (HbA1c).

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Collaborators

  • Rockefeller University

Registry information

Important dates

Study start
2018
Primary completion
2027
Study completion
2027
First posted
May 14, 2018
Registry last updated
Jul 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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