Overlooked Barrier To Discontinuing Bont-A Therapy

This study aims to evaluate patient adherence to botulinum toxin (BoNT-A) treatment and identify the factors contributing to its discontinuation.

This retrospective cohort study analyzed the medical records of patients who received at least one botulinum toxin treatment for post-stroke spasticity (PSS) from 2012 to 2024. Eighty-one enrolled patients responded to structured questions about their reasons for not consistently continuing BoNT-A treatment.

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Key information

Conditions

Post Stroke Spastic Hemiplegia Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Muscle Hypertonia Muscle Spasticity Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Stroke Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Süleyman Demirel University Faculty of Medicine Hospital

Isparta, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

included chronic-phase ischemic or hemorrhagic stroke and spasticity in the upper and/or lower limbs.

Exclusion criteria

Patients younger than 18 years, those who had passed away, and those who could not be reached by phone were excluded from the study.

Treatment and study plan

provide information by phone

Other

Previous studies did not question why patients thought they did not benefit from the injection. For example, the expectations of patients who said they did not benefit were excessive.

Primary outcomes

Primary Outcome

Time frame: 2012-2024

Most PSS patients received only one BoNT-A injection over 12 years
Primary Outcome

Time frame: 2012-2024

The primary reason cited for discontinuing BoNT-A therapy was a lack of awareness about the necessity of ongoing treatment.

Sponsors and collaborators

Lead sponsor

Suleyman Demirel University

Other

Registry information

Official study title

Is The Insuffıcıent Patıent Informatıon An Overlooked Barrıer To Dıscontınuıng Bont-A Therapy For Post-Stroke Spastıcıty? A Retrospectıve Cohort Study

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Feb 20, 2026
Registry last updated: Feb 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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