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NCT Number: NCT06236087

Overdose Prevention Centers and Behavioral Health

The aims of this study are: (Aim 1) Identify sources of heterogeneous impacts of opioid prevention center (OPC) use on non-fatal and fatal overdose risk among individuals with histories of polysubstance use (PSU); (Aim 2) Estimate the impact of OPC use on treated psychiatric events among clients with histories of PSU, and; (Aim 3) Assess the barriers and facilitators of integrating mental health services into existing syringe service and OPC delivery models.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

NYU Langone Health

New York, 10016, United States

About this study

Aims 1 and 2 of this study will use secondary data to identify sources of heterogeneous impacts of OPC use on fatal and nonfatal overdose risk (Aim 1) and estimate the impact of OPC use on treated psychiatric events among clients with histories of PSU (Aim 2). Aim 3 of this study will use qualitative interviews with harm reduction staff to assess barriers and facilitators of integrating mental health services into existing syringe service and OPC delivery models.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aims 1 and 2:

  • are 18 years of age or older;
  • engaged in syringe service program and/or overdose prevention center services in New York City in the past 30 days before the date of enrollment;
  • are able to complete assessments in English or Spanish;
  • are competent to give written informed consent at the time of the interview;
  • are able to provide informed consent;
  • self-report use of illicit opioids (e.g., heroin, fentanyl), illicit stimulants (e.g., powder cocaine, crack, methamphetamine), counterfeit prescription pills (defined as prescription pills obtained through the illicit drug market) or any injection drug use in the past 30 days, and
  • are able to participate for at least 6 months following enrollment.

Aim 3

  • are 18 years of age or older;
  • are employed by a harm reduction program;
  • are able to complete assessments in English; and
  • are able to provide informed consent.

Exclusion criteria

  • Individuals not meeting the criteria detailed above for the respective Aims will not be eligible for participation in this study.

Treatment and study plan

Primary outcomes

  1. Incidence of Fatal Overdose

    Time frame: Up to Month 12

    Incidence of fatal overdose will be derived from overdose mortality data from the NYC Office of the Chief Medical Examiner.

  2. Incidence of Non-Fatal Overdose

    Time frame: Up to Month 12

    Incidence of nonfatal overdose will be assessed using hospitalization and emergency department data from the NYC Regional Health Information Exchange (RHIO) and Statewide Research and Planning Cooperative System (SPARCS).

  3. Incidence of Psychiatric Services Utilization

    Time frame: Up to Month 12

    Psychiatric services utilization will be assessed from SPARCS, RHIO, and NYS Medicaid.

Study contacts

Contact information is provided by the study sponsor or research team.

Bennett Allen, PhD, MPA

CONTACT

[email protected]

646-501-3708

Sponsors and collaborators

Lead sponsor

NYU Langone Health

Other

Collaborators

  • Centers for Disease Control and Prevention

Registry information

Official study title

Assessing the Impact of Overdose Prevention Centers as a Polysubstance Use and Behavioral Health Intervention in New York City

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Feb 1, 2024
Registry last updated
Mar 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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