Overcontrol and Suicide in PTSD

High standards and self-discipline are prized in military culture, but drawbacks of overcontrol are often ignored. Overcontrol, a transdiagnostic phenotype, is characterized by over-regulated behavior and cognitive rigidity, driven by an intense need for perfection and control. It is prevalent in obsessive-compulsive (OC) spectrum disorders, especially OC Personality Disorder (OCPD). Their inclination to set high expectations for others often causes interpersonal tension straining social bonds. When grappling with mental health challenges, overcontrolled individuals often do so with limited social support and consequently, may have poorer outcomes.

Treatments enhancements are needed to improve interpersonal functioning, quality of life and mitigate suicide risk these vulnerable Veterans. Neuromodulation adjunctive to psychotherapy is a promising option. Key obstacles, however, impede the development of circuit-based treatments tailored to this phenotype: 1) limited validation of existing associations between interpersonal functioning and OCPD in a broader, overcontrolled sample, 2) the absence of a unified, transdiagnostic circuit model of overcontrol, and 3) robust methods for tracking gradual changes in individuals' functioning throughout the course of treatment.

This pilot project will develop methods to address these knowledge gaps. Specifically, the investigators aim to:

• Assess the feasibility of our recruitment strategy and evaluate interpersonal functioning in a cohort of trauma-exposed Veterans exhibiting overcontrolled traits.
• Test the feasibility and acceptability of a three-session, weekly fMRI protocol focused on the circuitry of overcontrol, while evaluating within-subject reliability of observed neural correlates.
• Examine the feasibility and acceptability of a three-week protocol for remote monitoring of weekly variance in socio-occupational functioning and emotional regulation.

In service of these Aims, the investigators plan to enroll and screen up to 74 Veterans aged 18-65 who are currently receiving care at either PVAMC's Trauma Recovery Clinic (TRC) or Women's Health Clinic (WHC), the latter included to boost female participation. All those who consent to participate will complete the screening assessment. Of these 74 screened participants, the investigators anticipate that 36 Veterans will meet our inclusion/exclusion criteria and will be invited to complete additional psychosocial assessments. A subset of participants (up to n=18) will be invited to complete three MRI sessions and six brief at-home assessments asking questions about stress, emotional regulation, and socio-occupational functioning.

Inclusion criteria

General Inclusion:

• All prospective participants must be able to comprehend the study's procedures and associated risks and be capable of providing informed consent.
• Mean scores on at least three subscales of the Pathological Obsessive Compulsive Personality Scale (POPS) must be greater than an average score of four (4 = "slightly agree") across subscale items.

• The POPS is a 49-item self-report assessment of maladaptive behaviors and thought patterns associated with OCPD.
• While Veterans with primary psychotic disorders will be excluded, the presence of other disorders related to obsessive-compulsive tendencies or personality will not be grounds for exclusion.
• Psychiatric medication usage will be assessed during enrollment, but this will not serve as an inclusion or exclusion criterion (with an additional stipulation outlined below for the MRI subsample).

Exclusion criteria

General Exclusion:

• The Mini International Neuropsychiatric Interview (M.I.N.I.) will be used to exclude participants with current psychosis or with past psychosis that was unrelated to depression.

Additional MRI Criteria:

• Participants interested in taking part in the MRI portion of the study will undergo a thorough screening to ensure MRI compatibility (e.g., absence of metal in the body, absence of claustrophobia).
• Interested participants must meet the following additional criteria:

• no medical contraindications for MRI (e.g., pacemakers, non-MRI safe implanted devices)
• absence of neurological disorders
• no moderate-to-severe traumatic brain injury (e.g., head trauma with loss of consciousness >5 minutes)
• no ongoing poorly controlled substance use disorder.
• Lifetime history of seizures, primary or secondary CNS tumors, stroke, or cerebral aneurysm will also be exclusionary.
• For participants in the MRI segment of the study, continued medication use will not be a disqualifying factor if the medication regimen has remained stable for the past month, with no intentions of altering dosages during the study duration.
• This medication criterion will not be applied to participants who do not complete MRI scans.
• For this feasibility trial, individuals exhibiting active suicidal behavior or a score >3 on the suicidal ideation module of the Columbia-Suicide Severity Rating Scale will be ineligible.