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Recruiting

NCT Number: NCT05830929

Ovarian Tissue Cryopreservation and Subsequent Auto-Transplantation for Female Cancer Patients

Ovarian Tissue Cryopreservation will be provided to cancer patients to allow them to have their fertility preserved.

Recruiting

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Key information

Conditions

Neoplasms

Age range

1 month–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

About this study

This project hopes to provide Ovarian Tissue Cryopreservation to patients who do not have adequate time for ovarian stimulation in oocyte or embryo freezing and in prepubertal girls where oocyte freezing is not possible. All the patients will have fertility preservation consultations with a fertility specialist in our unit to go through the details of ovarian Tissue Cryopreservation service and risks related to ovarian tissue cryopreservation procedures. After undergoing ovarian tissue collection via surgery, the collected ovarian tissue will be cryopreserved either by slow freezing or vitrification in our unit.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged from 0-35 years old and diagnosed with cancer e.g., leukaemia, myeloproliferative or myelodysplastic diseases, lymphoma, bone tumours, neurological neoplasms and sarcoma, Paediatric bone marrow transplant patients
  • Patients with any illness or who will undergo any type of treatment that may cause irreversible damage to their fertility, such as extensive abdominal surgery, high toxicity medication and treatments;
  • Patients suffering from hormone-sensitive malignancies who will undergo medical treatment, such as radiotherapy and chemotherapy that is liable to damage their ovaries and deter them from conception in the future.

Exclusion criteria

  • Patients with no anticipated oncologic therapies
  • Patients who are pregnant
  • Children with one ovary
  • Children deemed high risk for perioperative complications
  • Patients unable to provide consent/assent (i.e. significant psychiatric problems/cognitive delay)

Treatment and study plan

Ovarian tissue freezing and subsequent auto-transplantation after thawing

Procedure

Removal of the ovarian tissue will be retrieved via laparoscopic surgery under general anesthesia. The ovarian cortical tissue obtained will be transferred on ice to the laboratory for cryopreservation. After medical treatment, if the patient would like to start a family but has experienced premature ovarian failure, she will have ovarian tissue auto-transplantation after thawing.

Primary outcomes

  1. Surgical complications

    Time frame: 15 years

    Surgical complications after ovarian tissue transplantation

Secondary outcomes

  1. Pregnancy rate

    Time frame: 15 years

    Pregnancy rate after ovarian tissue transplantation

Study contacts

Contact information is provided by the study sponsor or research team.

Elaine NG, MPhil

CONTACT

[email protected]

+852 35052745

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Registry information

Important dates

Study start
2023
Primary completion
2043
Study completion
2043
First posted
Apr 26, 2023
Registry last updated
Jan 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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