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NCT Number: NCT07110285

Ovarian Stimulation Outcomes During a GnRH Antagonist Protocol for In-vitro Fertilization When Comparing Trigger Day Decision by Physicians Versus an Artificial Intelligence-based Algorithm.

To compare the number of mature oocytes following a GnRH antagonist in-vitro fertilization stimulation cycle when comparing trigger day timing decision by physicians versus an artificial intelligence-based algorithm

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Key information

Conditions

IVF Outcomes

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Herzliya Medical Center

Herzliya, 74077, Israel

Location status: Recruiting

Location contact

Ariel Hourvitz, MD

SUB_INVESTIGATOR

Michal Youngster

CONTACT

[email protected]

0506430111

Michal Youngster, MD

PRINCIPAL_INVESTIGATOR

About this study

Examination of all patients undergoing an ovarian stimulation cycle utilizing the GnRH antagonist protocol for oocyte cryopreservation or for fertilization via intracytoplasmic sperm injection (ICSI) (any treatment where oocytes are denuded and maturity may be assessed). The number of mature oocytes will be compared between cycles where trigger day timing was decided by the treating physician versus an artificial intelligence-based algorithm.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients undergoing an ovarian stimulation cycle utilizing the GnRH antagonist protocol for oocyte cryopreservation or for fertilization via intracytoplasmic sperm injection (ICSI) (any treatment where oocytes are denuded and maturity may be assessed).

Exclusion criteria

  • Loss to follow-up, patient retracts consent to participate

Treatment and study plan

Artificial intelligence-based algorithm

Other

Trigger day timing decision by an artificial intelligence-based algorithm

Primary outcomes

  1. Mature oocyte yield

    Time frame: 2 years

    The number of mature oocytes collected during a single egg retrieval cycle

Secondary outcomes

  1. Oocyte yield

    Time frame: 2 years

    Number of retrieved oocytes during an egg collection cycle

Study contacts

Contact information is provided by the study sponsor or research team.

Michal Youngster, MD

CONTACT

[email protected]

+972-50-643-0111

Sponsors and collaborators

Lead sponsor

FertilAI

Industry

Registry information

Official study title

Ovarian Stimulation Outcomes During a GnRH Antagonist Protocol for In-vitro Fertilization When Comparing Trigger Day Decision by Physicians Versus an Artificial Intelligence-based Algorithm - A Randomized Control Study.

Important dates

Study start
2025
Primary completion
2027
Study completion
2028
First posted
Aug 7, 2025
Registry last updated
Jan 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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