Ovarian Reserve in Intensive Care Patients

Gastrointestinal, pulmonary, nephrological, cardiac, neurologic and psychological effects in critically ill patients followed in the intensive care unit have been shown in the literature. However, the effects on ovarian reserve in these patients have not been sufficiently investigated and studies investigating this issue are limited in the literature. The synthesis, release frequency and amplitude of reproductive hormones change under stress. In addition, changes in ovarian homeostasis affect ovarian reserve. The aim of this study was to evaluate ovarian reserve in critically ill patients followed up in the intensive care unit.

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Key information

Conditions

Anti-Mullerian Hormone Deficiency

Age range

18 year–35 year

Sex eligibility

Female

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

18-35 years of age
Female patients followed in the intensive care unit for more than 24 hours for internal or surgical reasons,
Women whose ovarian reserve is being evaluated,

Exclusion criteria

Previous ovarian surgery, endometriosis, endometrioma,
History of chemotherapy, radiotherapy,
Ovarian cyst, malignancy and other ovarian pathologies,
Women with single ovary,
Women receiving hormone therapy,
Polycystic ovary syndrome,
Surgical intervention within the last 6 months,
History of drug, alcohol, substance use,
Women in pregnancy, puerperium, lactation,
History of vaccination within the last 6 months

Treatment and study plan

Glaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS)

Behavioral

The uterus, endometrium and ovarian characteristics, endometrial thickness, ovarian follicle number and ovarian volume parameters, hormone panel (FSH, LH, E2, AMH), cortisol, prolactin and thyroid function tests routinely examined for ovarian reserve will be evaluated in the study.

Primary outcomes

ovarian follicle count

Time frame: 24 hour

Ovarian reserve will be checked with ultrasound

Study contacts

Contact information is provided by the study sponsor or research team.

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CONTACT

[email protected]

905054525261

Sponsors and collaborators

Lead sponsor

Haseki Training and Research Hospital

Other

Registry information

Official study title

Evaluation of Ovarian Reserve in Critically Ill Patients Followed in the Intensive Care Unit

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: May 31, 2025
Registry last updated: May 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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