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OpenTrials
Completed

NCT Number: NCT03897400

Ovarian Reserve in Crohn's Disease

Crohn's disease reduces fertility by inducing inflammation both directly and in the fallopian tubes and ovaries and indirectly through surgical interventions and tubal adhesions associated with disease treatment. Anti-mullerian hormone (AMH) is a reliable indicator of ovarian reserve in women. The aim of this study was to compare serum AMH levels in women with Crohn's disease and healthy controls. In this study, the investigators aimed to investigate AMH and ovarian capacity in the study group with crohn's disease and in the control group without disease.

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Key information

Conditions

Crohn Disease Adnexal Diseases Anti-Mullerian Hormone Deficiency Digestive System Diseases Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Gastroenteritis Gastrointestinal Diseases Genital Diseases Genital Diseases, Female Gonadal Disorders Inflammatory Bowel Diseases Intestinal Diseases Ovarian Diseases Ovary Disease Urogenital Diseases

Age range

18 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Kanuni Sultan Süleyman Training and Research Hospital

Istanbul, 33404, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • crohn's disease;
  • reproductive age women

Exclusion criteria

  • Over 40 years old,
  • a previous ovarian resection;
  • renal failure (serum creatinine levels N1.2 mg / dL);suspicion of malignancy;
  • the presence of hereditary or acquired hematological disease;
  • pregnancy;
  • current lactation;
  • the presence of a serious comorbid chronic disease;
  • cirrhosis originating from chronic liver disease;
  • abnormal thyroid function tests;
  • a known serious psychological problem;
  • presence of alcoholism and male sex.

Treatment and study plan

AMH levels in young women with crohn's disease will be considered.

Other

Ovarian Reserve in Young Women of Reproductive Age with Crohn's Disease;Blood will be taken from both the study and control groups and the AMH level will be evaluated.

Primary outcomes

  1. AMH levels

    Time frame: 1 MONTH

    AMH levels of subjects taken into groups will be evaluated in lg/L

Secondary outcomes

  1. ultrasound findings

    Time frame: 1 MONTH

    On the 3rd day of the menstrual cycle, the patients will be given ultrasound and the ovarian volume will be examined. the ovarian volume will be calculated by taking the size of the ovary in three sections.

Sponsors and collaborators

Lead sponsor

Kanuni Sultan Suleyman Training and Research Hospital

Other

Registry information

Official study title

Evaluation of Ovarian Reserve in Crohn's Disease

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Apr 1, 2019
Registry last updated
Oct 23, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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