Outcomes of Posterior Urethral Valve Fu… | Clinical Trial

Key information

Conditions

Posterior Urethral Valve

Sex eligibility

Male

Study type

Observational

About this study

Posterior Urethral Valves (PUV) are the most common cause of lower urinary tract obstruction. More severe forms are detected early in pregnancy (mainly type I), while other forms are usually discovered later in childhood when investigating lower urinary tract symptoms. Bladder dysfunction is common and is associated with urinary incontinence in about 55% (0%-72%). Despite the removal of the obstruction by urethral valve ablation, pathological changes in the urinary tract can occur with progressive bladder dysfunction, which can cause deterioration of the upper urinary tract as well. For this reason, all children with PUV require long-term follow-up, always until puberty. In many cases, the life-long current status is uncertain. The current literature lacks research on long-term outcomes.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with fulguration of PUV since 1 year or more

Exclusion criteria

Patients with neurogenic bladder or meningocele or spina bifida .

Patients with renal parenchymal disease and inflammation not related to posterior urethral valve .

Diabetic patients .

Parental refusal .

Treatment and study plan

Fulguration

Procedure

Posterior urethral valve fulguration

Primary outcomes

The rate of spontaneous voiding with insignificant or absent PMR ( according to equation to age ) after one year from fulguration of the PUV.

Time frame: One year postoperative

Study contacts

Contact information is provided by the study sponsor or research team.

Keroles Ashraf Soliman Eskaros Dr

CONTACT

[email protected]

+201061875665

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Long-term Evaluation of Patients With Fulguration of Posterior Urethral Valve: A Retrospective Cohort Study

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2027
First posted: Mar 10, 2025
Registry last updated: Mar 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed