Outcomes of Neoadjuvant Therapy for Rectal Cancer in a Tertiary Asian Institute

This is a retrospective cohort study that aims to evaluate the correlation of magnetic resonance tumour regression grade (mrTRG) and pathological TRG (pTRG) of locally advanced rectal cancer after neoadjuvant long course chemoradiotherapy as well as the prognostic value of mrTRG on survival.

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Key information

Conditions

Rectal Cancer Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Oncology Rectal Diseases Rectal Neoplasms

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Rectal cancer
At least 1 high risk feature on MRI
Undergo long course neoadjuvant chemoradiotherapy (LCCRT)

Exclusion criteria

metastatic disease
Patients who undergo short course radiotherapy
Patients without a repeat MRI after completion of LCCRT

Treatment and study plan

neoadjuvant long course chemoradiotherapy

Radiation

neoadjuvant long course chemoradiotherapy consist of radiosensitizing 5FU or capecitabine and 50.4 Gy in 28 fractions over 5 weeks

Primary outcomes

Correlation between mrTRG and pTRG

Time frame: Between 1 Jan 2011 to 31 Dec 2016

Secondary outcomes

Prognostic value of mrTRG on survival outcomes of rectal cancer patients

Time frame: Between 1 Jan 2011 to 31 Dec 2016

Sponsors and collaborators

Lead sponsor

Singapore General Hospital

Other

Registry information

Official study title

Outcomes of Neoadjuvant Therapy for Rectal Cancer in a Tertiary Asian

Important dates

Study start: 2011
Primary completion: 2016
Study completion: 2019
First posted: Nov 7, 2022
Registry last updated: Nov 7, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed