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OpenTrials
Completed

NCT Number: NCT02293668

Outcome of Three Controlled Ovarian Hyperstimulation Protocols in Poor Responding Infertility Patients

There are different controlled ovarian hyperstimulation protocols utilized in infertility patients. In this study, our aim is to specifically compare three protocols in poor responding infertility patients.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year–42 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Istanbul University School of Medicine

Istanbul, 34093, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients will be considered eligible if they are poor ovarian responders according to the Bologna criteria (Ferraretti et al., 2011).
  • Two out of three of the following criteria are essential in order to classify a patient as poor ovarian responder:
  • advanced maternal age (≥40 years) or any other risk factor for poor ovarian response;
  • a poor ovarian response (≤3 oocytes with a conventional stimulation protocol); or
  • an abnormal ovarian reserve test (antral follicle count, <7 follicles or anti-Mullerian hormone, <1.1 ng/ml).

Treatment and study plan

FSH 225IU and hMG 225IU

Drug

FSH 150IU and hMG 150IU

Drug

Letrozole 5mg and hMG 150IU

Drug

Primary outcomes

  1. Clinical pregnancy rate

    Time frame: 8 weeks

Secondary outcomes

  1. Number of oocytes retrieved

    Time frame: 4 weeks

  2. Number of transferable embryos

    Time frame: 4 weeks

  3. Biochemical pregnancy rate

    Time frame: 6 weeks

Sponsors and collaborators

Lead sponsor

Istanbul University

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Nov 18, 2014
Registry last updated
Jan 8, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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