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NCT Number: NCT06608771

Outcome of Cardiac Arrest Patients Following Guidelines Implementation Over the Years

The study aims to evaluate the level of local implementation of the new interventions introduced by the guidelines for post-cardiac arrest management and their impact on the survival of patients resuscitated from cardiac arrest and admitted to intensive care over a 14-year period. During this time period, the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) introduced three new guidelines for post-cardiac arrest management, each five years apart: the 2010, 2015, and 2021 guidelines.

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Key information

Conditions

Cardiac Arrest Cardiovascular Diseases Heart Arrest Heart Diseases Out-of-Hospital Cardiac Arrest

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondazione IRCCS San Gerardo dei Tintori, Monza, Monza E Brianza, Italy

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About this study

This study is a retrospective multicenter cohort observational study (two centers involved: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Fondazione IRCCS San Gerardo dei Tintori).

All patients admitted to the Intensive Care Units (ICU) of the hospitals involved in the study from January 1, 2011, to May 30, 2024, following cardiac arrest of any etiology, who meet the inclusion and exclusion criteria, will be enrolled.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients resuscitated from cardiac arrest and admitted to intensive care unit
  • Age ≥ 18 years
  • Out-of-hospital and in-hospital cardiac arrest
  • Cardiac arrest of any etiology

Exclusion criteria

  • Pediatric patients (<18 years)
  • Patients not admitted to one of the aforementioned intensive care units.

Treatment and study plan

Primary outcomes

  1. Intensive Care Unit (ICU) Survival

    Time frame: From cardiac arrest date to ICU discharge or death, up to 90 days

    To evaluate ICU survival for patients resuscitated from cardiac arrest

  2. Neurological recovery at ICU discharge

    Time frame: From cardiac arrest date to ICU discharge or death, up to 90 days

    ICU Survival with Cerebral Performance Category (CPC) score of 1 or 2

Secondary outcomes

  1. Hospital discharge status

    Time frame: From cardiac arrest date to hospital discharge or death, up to 180 days

    To evaluate hospital survival for patients resuscitated from cardiac arrest

Study contacts

Contact information is provided by the study sponsor or research team.

Giuseppe Ristagno, MD, PhD

CONTACT

[email protected]

+390255033258

Mauro Panigada, MD

CONTACT

[email protected]

+390255033258

Sponsors and collaborators

Lead sponsor

Mauro Panigada

Other

Registry information

Official study title

Implementation of the New Guidelines on the Management of Patients Resuscitated From Cardiac Arrest and Impact on Survival: a Multicenter Retrospective Observational Study

Acronym: IMPACT-ACC

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Sep 23, 2024
Registry last updated
Sep 23, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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