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OpenTrials
Completed

NCT Number: NCT02671812

Outcome After Dental Implant Treatment

The general aim of this project is to investigate the long-term treatment outcome after implant therapy. The patients' satisfaction with implant treatment will be studied and correlated to biological and technical problems. The survival rates of implants at patient level and the degree of bone loss of remaining teeth and implants will be calculated. The levels of cytokines and bone loss markers in peri-implantitis sites and periodontal defects and at healthy sites will be analyzed in order to study the correlation between cytokine and bone loss marker levels, and clinical conditions. Independent variables which could be regarded as significant risk factors or risk predictors on the incidence of peri-implantitis are aimed to be identified

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Key information

About this study

  • A questionnaire study will investigate patient satisfaction 8-14 years after dental implant therapy to study if complications influence the degree of satisfaction/quality of life. The questionnaire will be sent to 587 patients treated at The Specialist Clinic Skanstull.
  • A clinical examination of a minimum 150 patients who answered the questionnaire will be performed:
  • to study the incidence of biological and technical complications on dental implants after a minimum of 10 year of function.
  • to study the survival rates of implants at patient level and the degree of bone loss of remaining teeth and implants. In addition, the correlation between bone loss of remaining teeth and bone loss of implants will be studied.
  • samples taken from the gingival crevicular fluid to investigate the profile of cytokines and bone resorption markers as well as to study the intra-individual correlation of cytokines and bone markers in gingival crevicular fluid from sites with peri-implantitis and periodontal defects in individuals with dental implants.
  • in addition, the salivary cytokine and bone resorption markers will be analyzed in order to identify disease-specific biomarkers as well as to study the correlation between the cytokine/bone resorption markers in saliva and in gingival/peri-implant crevicular fluid.
  • To identify significant risk factors or risk predictors on the incidence of peri-implantitis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Treated at the Specialist Clinic Skanstull, Stockholm, Sweden with dental implants between the years of 1999-2005

Exclusion criteria

  • Deceased before or during the study period

Treatment and study plan

Primary outcomes

  1. Patients satisfaction after dental implant treatment

    Time frame: 10 years after implant treatment

    Questionnaire and clinical examination

Secondary outcomes

  1. Complications prevalence

    Time frame: 10 years after implant treatment

    Self reported and registered in patients journal and detected at the clinical examination

  2. Profile of inflamatory markers

    Time frame: 10 years after implant treatment

    Samples of saliva and gingival fluid from healthy and disease sites at both tooth and dental implants will be analyzed

Sponsors and collaborators

Lead sponsor

Folktandvården Stockholms län AB

Other Gov

Collaborators

  • Karolinska Institutet

Registry information

Official study title

Longterm Outcome After Dental Implant Treatment

Important dates

Study start
2014
Primary completion
2018
Study completion
2018
First posted
Feb 2, 2016
Registry last updated
Jan 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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