Skip to main content
OpenTrials
Completed

NCT Number: NCT04097847

Osteoradionecrosis and PENTOCLO Protocol: Retrospective Study

osteoradionecrosis (ORN) affects up to 30% of irradiated patients and can occur up to several decades after stopping treatment. Differents therapeutics exist but there is no consensus concerning the management of the maxillary ORN. The understanding of new pathological mechanisms opens the way to new therapeutic perspectives.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Osteoradionecrosis of Jaw

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU de Brest

Brest, 29609, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient over 18 being or having been treated by pentoclo combination for an osteoradionecrosis of the jaw

Exclusion criteria

  • Tumoral recidivism
  • Precocious stop of pentoclo

Treatment and study plan

Pentoxifylline-Tocopherol-Clodronate

Drug

the aim of this retrospective study is to analyze from patient records the impact of the PENTOCLO protocol on maxillofacial osteoradionecrosis at Brest Hospital University, France.

Other names: Pentoclo

Primary outcomes

  1. Clinical evolution of the osteoradionecrosis lesion after introducing PENTOCLO protocol

    Time frame: 2 years

    Retrospective study based on recovering patient data from medical records

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Registry information

Official study title

Osteoradionecrosis and PENTOCLO Protocol: Retrospective Study.

Acronym: OPEN

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Sep 20, 2019
Registry last updated
Nov 1, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.