Skip to main content
OpenTrials
Completed

NCT Number: NCT02160613

Osteoprotegerin Before and After Periodontal Surgery

The study hypothesis:

Is Osteoprotegerin a diagnostic and/or prognostic marker of periodontal disease?

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Chronic Periodontitis Chronic Disease Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

32 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of oral and dental medicine

Cairo, Egypt

About this study

assessment of osteoprotegerin in patients with chronic periodontitis before and after periodontal surgery in gingival crevicular fluid, saliva and gingival tissues.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • severe chronic periodontitis, having pocket depth of ≥ 5 mm and clinical attachment level ≥ 5 mm

Exclusion criteria

  • pregnant women
  • subjects had <22 permanent teeth
  • having any given systemic disease
  • taking any type of medication and/or antibiotic therapy during the 3 months before the study
  • received periodontal treatment within the past 12 months
  • current or former smokers.

Treatment and study plan

Open Flap debridement

Procedure

an access flap

Primary outcomes

  1. Change from baseline in Osteoprotegerin levels at 3 and 6 months

    Time frame: Baseline, 3 months and 6 months

Secondary outcomes

  1. changes from baseline in Clinical attachment level at 3 and 6 months.

    Time frame: Baseline, 3 months and 6 months

  2. Changes from baseline in probing pocket depth at 3 and 6 months

    Time frame: baseline, 3 months and 6 months

  3. Changes from baseline in plaque index at 3 and 6 months

    Time frame: baseline, 3 months and 6 months

  4. Changes from baseline in gingival index at 3 and 6 months

    Time frame: baseline, 3 months and 6 months

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Effect of Periodontal Surgery on Osteoprotegerin Levels in Gingival Crevicular Fluid, Saliva and Gingival Tissues.

Important dates

Study start
2013
Primary completion
2013
Study completion
2014
First posted
Jun 10, 2014
Registry last updated
Jun 10, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.