Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement

In order to define the link between the characteristics of the oscillations (frequency, amplitude, phase relation) within this cortico-subcortical network and movement (normal or pathological) in humans, a simple motor task of gripping/pulling a lever has been designed.

The local field potentials (LFPs) will be collected during the same motor task in :

i) patients with Parkinson's disease, using a high-resolution electroencephalogram (EEG) and the PERCEPT(TM) system (Medtronic) equipped with a "sensing" function for deep LFP recordings and in EEG-HR (for high resolution) for cortical recordings

ii) patients with focal drug-resistant epilepsy, during a pre-surgical assessment by stereo-electro-encephalography (SEEG). The SEEG allows the recording of both the cortex and the subcortical regions in a concomitant manner, and a direct correlation can be studied.

Inclusion criteria

• Male or Female
• Between 18 and 75 years of age
• With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device.
• Giving free, informed, written consent signed by the participant and the investigator Or
• With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
• With at least one electrode exploring the basal ganglia or the thalamus.
• Able to perform the simple motor task
• Affiliated or beneficiary of a social security scheme;
• Giving free, informed, written consent signed by the participant and the investigator

Exclusion criteria

• Be incapable of giving consent personally
• Be subject to a legal protection measure or be placed under judicial protection;
• Being pregnant or breastfeeding
• Present a serious and/or decompensated somatic or psychiatric illness