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NCT Number: NCT07397221

Oropharyngeal Humidification After Extubation on Thirst

In patients who have undergone endotracheal intubation following cardiac surgery, symptoms such as thirst, dysphagia (difficulty swallowing), restlessness, nausea, and vomiting are frequently observed, and these conditions negatively affect the patients' overall comfort. Especially in the post-intubation period, dryness in the mouth and throat, an intense feeling of thirst, and difficulty swallowing can lead to feelings of suffocation, helplessness, fear, and anxiety in patients. Effective management of these symptoms is critically important both for accelerating the recovery process and for increasing patient satisfaction.

Traditionally, methods such as moistening the mouth with a cotton swab have been used to relieve complaints like thirst and dry mouth. However, these practices are often insufficient and have limited effectiveness in increasing patients' comfort. In recent years, the use of oropharyngeal sprays has emerged as an innovative and effective approach to alleviate symptoms such as thirst and dry mouth. In a randomized controlled trial conduct, it was shown that a spray-based oropharyngeal moisturizing program significantly reduced the severity of thirst and discomfort in patients who underwent intubation after cardiac surgery. Thirst and discomfort scores were found to be significantly lower in the spray-applied groups compared to the control group, and no significant difference was observed between the groups in terms of dysphagia frequency or adverse events. Similarly, studies conducted in different surgical and intensive care populations have shown that applications of cold water or cold saline sprays significantly reduce complaints of thirst and dry mouth, increase patient comfort, and are safe to use.

Additionally, it has been reported that alternative approaches such as menthol lozenges or aromatherapy also have positive effects on thirst, nausea, and comfort after cardiac surgery. Examining the effects of oropharyngeal sprays and similar practices on parameters such as thirst, dysphagia, discomfort, nausea, vomiting, and overall comfort in patients who are intubated after cardiac surgery may contribute to the development of innovative and effective approaches in patient care. Integrating such practices into postoperative care protocols carries significant potential for increasing patient comfort and supporting the recovery process.

This randomized controlled study aims to investigate the effects of oropharyngeal humidification after extubation on thirst, pain, and anxiety in patients undergoing coronary artery bypass surgery.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sancaktepe Şehit Prof. Dr. İlhan Varank Eğitim ve Araştırma Hastanesi

Istanbul, Turkey (Türkiye)

Location contact

Barış Özdere, Ph. D.

SUB_INVESTIGATOR

Betül İlbey Koç, Ph. D.

SUB_INVESTIGATOR

Fatma Eti Aslan, Prof. Dr.

SUB_INVESTIGATOR

Ömer Taşçı, Ph. D.

CONTACT

[email protected]

+90 0436 212 49 49

ömer taşçı, Ph. D.

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-65
  • Undergoing coronary artery bypass surgery
  • Postoperative mechanical ventilation and extubation
  • Able to provide informed consent

Exclusion criteria

  • Neuromuscular diseases (e.g., stroke, Parkinson's disease)
  • Head/neck deformities
  • Pre-existing dysphagia
  • Tracheostomy
  • Inability to participate in assessments

Treatment and study plan

Oropharyngeal Humidification with Water Spray

Other

Room-temperature drinking water is administered as an oral spray to multiple areas of the oral cavity (upper jaw, lower jaw, left and right cheek, and tongue). The researcher applies the spray twice per hour for 4 hours after extubation in patients undergoing coronary artery bypass surgery.

Primary outcomes

  1. Thirst Severity

    Time frame: Baseline (immediately after extubation) 2 hours post-intervention 4 hours post-intervention

    The Numeric Rating Scale is used for patients to indicate the severity of their thirst. Patients will be asked to rate their feeling of thirst on a scale from 0 to 10. A score of 0 means no thirst at all. An increase in the score indicates increasing thirst. A score of 10 represents extreme thirst.

Secondary outcomes

  1. Thirst-Related Discomfort

    Time frame: Baseline (immediately after extubation) 2 hours post-intervention 4 hours post-intervention

    The Perioperative Thirst Discomfort Scale is a 3-point Likert-type scale consisting of a total of 7 items. The rating is as follows: Did not disturb (0), Slightly disturbed (1), and Greatly disturbed. The scale does not have any sub-dimensions. Higher scores indicate greater thirst. The total score on the scale ranges from a minimum of 0 to a maximum of 12.

  2. Pain Severity

    Time frame: Baseline (immediately after extubation) 2 hours post-intervention 4 hours post-intervention

    Visual Analog Scale is used to assess pain. The patient's pain is evaluated with a score between 0 and 10. A score of 0 indicates no pain, while a score of 10 represents unbearable pain. An increase from 0 to 10 indicates increasing pain.

  3. Anxiety Level

    Time frame: Baseline (immediately after extubation) 2 hours post-intervention 4 hours post-intervention

    The State Anxiety Scale is a 20-item, 4-point Likert-type scale. The rating is as follows: Almost never (1), Sometimes (2), Often (3), and Almost always (4). As the score increases, anxiety also increases. The minimum total score on the scale is 0, and the maximum is 80.

  4. Post-Extubation Complications

    Time frame: Continuous monitoring during the 4-hour intervention period

    Complications such as coughing, oxygen desaturation, nausea-vomiting, or dysphagia are recorded.

Study contacts

Contact information is provided by the study sponsor or research team.

Ömer Taşçı, Ph. D.

CONTACT

[email protected]

+90 0436 212 49 49

Sponsors and collaborators

Lead sponsor

Muş Alparslan University

Other

Registry information

Official study title

The Effect of Oropharyngeal Humidification After Extubation on Thirst, Pain, and Anxiety in Patients Undergoing Coronary Artery Bypass Surgery: A Randomized Controlled Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 9, 2026
Registry last updated
Feb 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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