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OpenTrials
Completed

NCT Number: NCT05673226

Organosilane for Surface Cleaning in Intensive Care Units

The purpose of this study is to evaluate if surface disinfection with organosilane associated with traditional cleaning reduces the incidence of healthcare-associated infections (HAIs) in intensive care units when compared with traditional cleaning alone.

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Key information

Conditions

Infection, Hospital Catheter-Related Infections Cross Infection Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Healthcare-Associated Pneumonia Iatrogenic Disease Infections Lung Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Ventilator-Associated Respiratory Tract Diseases Respiratory Tract Infections Urinary Tract Infections Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Santa Casa de Misericórdia, Belo Horizonte, Brazil

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients aged 18 years and older who will be admitted to the participating ICUs

Exclusion criteria

  • Patients under 18 years
  • ICUs that may use any organosilane formulation for surface disinfection

Treatment and study plan

Surface disinfection with Organosilane

Other

Organosilane will be sprayed on the surfaces, using an atomizer. When the environment has been completely covered (i.e., when all surfaces and equipment have a slightly damp film), we will proceed with the second phase of the disinfection of all heavily touched surfaces. surfaces of the bed, with a microfiber cloth with organosilane.

Primary outcomes

  1. Incidence of healthcare associated infections

    Time frame: 6 months

Secondary outcomes

  1. Contamination of environmental surfaces by multi-resistant microorganisms

    Time frame: 6 months

    We will collect environmental samples from 4 surfaces highly touched by the patient, health team and family (bed rails, monitor and infusion pump buttons, meal table or procedure table, and IV drip stand) before and after the intervention. (end of the 6 months). For analysis of the environmental samples, characterization of the density and microbiological profile of biofilms on the different surfaces of the ICU beds will be performed using large-scale DNA sequencing techniques associated with bioinformatics analysis.

  2. Incidence of ventilator-associated pneumonia

    Time frame: 6 months

  3. Incidence of central line-associated blood stream infections

    Time frame: 6 months

  4. Incidence of catheter-associated urinary tract infection

    Time frame: 6 months

  5. Intensive care unit length of stay costs

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Hospital Israelita Albert Einstein

Other

Collaborators

  • Beneficência Portuguesa de São Paulo
  • Hospital Alemão Oswaldo Cruz
  • Hospital Moinhos de Vento
  • Hospital Sirio-Libanes
  • Hospital do Coracao

Registry information

Official study title

Organosilane for Surface Cleaning in Intensive Care Units: A Cluster Randomized, Controlled, Crossover, Clinical Trial

Acronym: ORG-CLEAN

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Jan 6, 2023
Registry last updated
Sep 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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