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OpenTrials
Completed

NCT Number: NCT00518908

Organ Protection With Sevoflurane Postconditioning

Organ protection, volatile anesthetics, postconditioning, hepatic surgery

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Key information

Conditions

Hepatectomy Cardiovascular Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Reperfusion Injury Vascular Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital of Zurich

Zurich, Switzerland

About this study

This study aims at the evaluation of a potential attenuation of ischemic-reperfusion injury in the liver with sevoflurane postconditioning upon reperfusion.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • older than 18 years
  • patients undergoing liver resection (benign or malignant tumors)

Exclusion criteria

  • non-german speakers
  • laparoscopic liver resection
  • coagulopathy (platelets < 50'000/ml, Quick < 50%)
  • liver cirrhosis

Treatment and study plan

Sevoflurane

Drug

3.2 Vol % for postconditioning

Primary outcomes

  1. Liver transaminase AST

    Time frame: Postoperative phase until discharge

    Peak value

Secondary outcomes

  1. ALT peak value

    Time frame: Postoperative phase until discharge

  2. Course of transaminases

    Time frame: From the day before surgery, to 6 hours after surgery, up to postoperative day 7

  3. Postoperative complications

    Time frame: Postoperative phase until discharge

  4. Length of hospital stay

    Time frame: Postoperative phase until discharge

  5. Need for prolonged intensive care unit stay (>24 hours)

    Time frame: Postoperative phase until discharge

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Official study title

Role of Volatile Anesthetics for Hepatic Protection in Ischemia-reperfusion: Postconditioning

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Aug 21, 2007
Registry last updated
Jul 19, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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