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OpenTrials
Completed

NCT Number: NCT00924222

Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass

Organ protection, volatile anesthetics, postconditioning.

Sedation of patients on ICU after cardiac surgery with cardiopulmonary bypass with either propofol or sevoflurane. Evaluation of organ function and inflammatory mediators in the blood.

Completed

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Key information

Conditions

Cardiac On-pump Surgery

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zurich, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • CABG and/or heart valve surgery with CPB
  • Ejection fraction (EF) = 30%
  • Canadian Cardiovascular Society (CCS) classification = 3
  • Ages 18 to 90 years old

Exclusion criteria

  • Pulmonary disease: forced expiratory volume in one second (FEV1) < 80%; FEV1/forced vital capacity (FVC) < 70%
  • Renal disease and/ or creatinine-clearance < 60 ml/min
  • Previous cardiac surgery
  • Emergency procedures
  • Postoperative intra aortic balloon pump (IABP) requirement
  • Myocardial infarction < 7d
  • Steroid treatment
  • Insulin-dependent diabetes
  • Pregnancy

Treatment and study plan

Sevoflurane

Drug

Sedation with sevoflurane

Propofol

Drug

Sedation on intensive care unit with propofol

Primary outcomes

  1. Myocardial injury markers (myoglobin, creatine kinase, myocard specific creatine kinase, and troponin T)

    Time frame: Start and end of ICU stay

Secondary outcomes

  1. Oxygenation index, postoperative pulmonary complications, ICU stay (days), length of hospitalisation

    Time frame: Start with surgery until end of hospitalisation

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Important dates

Study start
2007
Primary completion
2009
Study completion
2009
First posted
Jun 18, 2009
Registry last updated
Oct 12, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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