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OpenTrials
Completed

NCT Number: NCT06242015

Ordered Eating and Acute Exercise

There is well documented evidence that ingesting dietary carbohydrate in large amounts tends to increase postprandial glucose. In healthy populations, this is not necessarily a problem, but continuous exposure to high levels of glucose-hyperglycemia-is a defining characteristic and risk factor for type 2 diabetes mellitus. Consuming a carbohydrate-rich food as the final food in a meal sequence has been shown to significantly reduce postprandial glucose excursions in both diabetes patients and in healthy controls. The exact mechanisms behind this phenomenon are not well understood, but one proposed course is simply that the vegetable and protein already being digested slows the rate of glucose rise.

Despite the findings, little-to-no research has examined how manipulating the order of foods in a meal impacts subsequent exercise responses. In this experimental crossover study, each participant will undergo two acute feeding conditions (carbohydrate-rich foods first vs. last in a meal), which will be followed by exercise 60 minutes later. We will observe the effects of meal order on postprandial glucose, substrate/fuel utilization, and subjective perceptions at rest and during 30 minutes of exercise.

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

ODU Human Performance Laboratory

Norfolk, Virginia, 23529, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Currently physically active (scheduled exercise at least three days per week for 30 minutes each time over the last three months)
  • Ability to perform moderate-to-high intensity running for at least 30 minutes

Exclusion criteria

  • Any allergy or other condition that would prohibit the consumption of poultry, rice, or broccoli
  • Any injury or disease (cardiovascular disease, diabetes, pulmonary disease except controlled asthma) precluding physical exercise
  • Currently pregnant
  • Implanted electrical devices such as a pacemaker.

Treatment and study plan

Carbohydrate-first meal

Other

Rice (150 grams) eaten first, followed by broccoli (150 grams) and chicken (100 grams)

Carbohydrate-last meal

Other

Broccoli (150 grams) and chicken (100 grams) eaten first, followed by rice (150 grams)

Primary outcomes

  1. Postprandial glucose

    Time frame: 2 hours (premeal and 30, 60, 90, and 120 minutes after eating)

    Blood glucose will be measured with fingerstick samples and a portable glucometer

Secondary outcomes

  1. Carbohydrate use

    Time frame: 100 minutes (premeal and continuously for 90 minutes after eating)

    Carbohydrate utilization will be estimated from respiratory gas exchange

  2. Fat use

    Time frame: 100 minutes (premeal and continuously for 90 minutes after eating)

    fat utilization will be estimated from respiratory gas exchange

  3. Hunger-satiety perceptions

    Time frame: 2 hours (Premeal and at 15, 30, 45, 60, 68, 78, 88, 120 minutes after eating)

    Hunger, appetite, satiety, and fullness on a 0-10 Likert scale

  4. Rating of perceived exertion

    Time frame: 30 minutes (at 8, 18, 28 minutes of exercise)

    Rating of effort during 30-minute exercise bout

Sponsors and collaborators

Lead sponsor

Old Dominion University

Other

Registry information

Official study title

The Effect of Ordered Eating on Postprandial Glucose and Substrate Utilization During an Acute Exercise Bout

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Feb 5, 2024
Registry last updated
Aug 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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