Skip to main content
OpenTrials
Completed

NCT Number: NCT04049734

Oral Losartan in Prevention of Post-ERCP Paancreatitis

Oral losartan given in the dose of 50 mg one hour before ERCP was studied in the prevention of post ERCP pancreatitis in 50 patients indicated for ERCP in comparison with another 50 patients underwent ERCP without receiving oral losartan.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Post-ERCP Acute Pancreatitis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Any adult patient indicated for ERCP
  • Patients with obstructive jaundice.
  • Patients with dilated intra-hepatic or extra-hepatic bile ducts due to malignant or benign lesions.

Exclusion criteria

  • Patients refusing to undergo the procedure or signing the informed consent
  • Patients with clinically evident acute pancreatitis before the procedure
  • Patients with previous endoscopic or surgical sphincterotomy
  • Patients with current use of losartan
  • Patients who are allergic or hypersensitive to losartan or hydro soluble contrast solutions
  • Patients receiving NSAIDS within a week prior to assessment
  • Patients with severe co-morbid conditions as cardiovascular disease, renal failure or decompensated liver cirrhosis.

Treatment and study plan

oral losatan

Drug

50 mg of oral losartan one hour before the ERCP once

Primary outcomes

  1. Number of participants with development of acute pancreatitis

    Time frame: 24 hours

    Number of participants with development of abdominal pain and elevated serum amylase and/or lipase

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Evaluation of Oral Losartan in the Prevention of Post-ERCP Pancreatitis

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Aug 8, 2019
Registry last updated
Aug 9, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.