Oral Lactobacillus Crispatus LCr86 Reduces Nugent Score and Improves Vaginal Microecology in Women With Intermediate Vaginal Microbiota

Inclusion criteria

• Women of childbearing age over 19 years of age and under 50 years of age.
• A person with a score of 4-6 on the Nugent core.
• A person who agrees to participate in the human application test before the human application test begins and has prepared the written consent form.
• A person who agrees to follow the contraception methods permitted by PI.

Exclusion criteria

• Those who are currently being treated for severe cardiovascular system, immune system, respiratory system, gastrointestinal tract/liver and biliary system, kidney and urinary system, nervous system, musculoskeletal system, psychiatric, infectious disease, tumor and malignant.
• The subjects who treated for vaginal or urinary tract infection as of within 3 months (e.g., candidiasis, trichomonas infection, gonorrhea, chlamydial infection, etc.).
• The subjects with vaginal or urinary tract bleeding, or abnormality.
• The subjects who has been given antibiotics, antimicrobial agents, steroids, immunosuppressants, estrogen-based drugs (pneumonia-related drugs are allowed) within 4 weeks of visit 1 (but those who used them within 2 weeks of visit 1 cannot participate in the test).
• The subjects who has consumed health functional foods related to improving immune function and vaginal health.
• The subjects who has administered probiotics and prebiotics within two weeks based on visit 1 or has continuously administered or ingested fermented milk and lactobacillus products.
• Allergic constitution or hypersensitivity to known components of the study drug.
• The subjects who has received salivary treatment for sedimentation, women's cleansers, vaginal sanitizers, left fumigation, and vaginal health within two week of screening visit.
• The subjects with unregulated hypertension (above 160mmHg or 90mmHg of blood pressure).
• The subjects who AST (GOT) or ALT (GPT) is at least three times the normal limit of the testing agency.
• The subjects who are sensitive or allergic to the ingredients of this human-applied test food.
• Subjects who are pregnant, breastfeeding, or planning to conceive within three months.
• If the daily alcohol intake is more than 20g.
• Excessive smokers (≥20 pieces/day).
• The subjects who has participated in another interventional clinical trial within three month of the commencement of this trial or who has a plan to participate in another interventional clinical trial (including a human application test) after the commencement of this human application test.
• The subjects who is deemed inappropriate by the human application test testers for this human application test.
• Other vaginitis: Trichomonas vaginalis (TV) infection or fungal infection.