Oral Immunotherapy for Peanut and Mammalian Meat Allergies

Pilot study to assess the effect of oral immunotherapy on specific Immunoglobulin E (IgE) levels and antigen consumption in two distinct food allergies.

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Key information

Conditions

Food Hypersensitivity Hypersensitivity Hypersensitivity, Immediate Immune System Diseases

Age range

4 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Virginia

Charlottesville, Virginia, 22908, United States

About this study

In subjects with mammalian meat allergy, the effect of daily oral cow's milk on immune parameters and desensitization will be assessed. Similarly, in subjects with a peanut allergy the effects of low dose peanut flour will be assessed and comparisons between two distinct food allergies.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Presence or absence of specific IgE to alpha-gal or peanut

Exclusion criteria

History of severe anaphylaxis
allergy to cow's milk protein

Treatment and study plan

cow's milk

Dietary Supplement

daily consumption of cow's milk

peanut powder

Dietary Supplement

peanut oral immunotherapy

Primary outcomes

The Level of Allergen Consumed Post-oral Immunotherapy

Time frame: Following 36 months of maintenance oral immunotherapy, participants completed an open challenge at month 37

consumption of cow's milk or peanut flour at open challenge. This is a single time-point assessment; not measured repeatedly.

Sponsors and collaborators

Lead sponsor

University of Virginia

Other

Registry information

Important dates

Study start: 2012
Primary completion: 2014
Study completion: 2015
First posted: Jan 30, 2015
Registry last updated: Nov 3, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed