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NCT Number: NCT07020078

Oral Health Condition Among a Group of Ionizing Radiation Field Workers

The goal of this study is to test the effect of ionizing radiation on salivary Redox status among a group of ionizing radiation workers by measuring salivary biomarkers(malondialdehyde,8_hydroxy_deoxyguanosine and catalase) and measuring oral health condition by plaque index.

90 male subjects will be enrolled in this study between 30_40 years old worked in Baghdad teaching hospital ,30 subjects exposed from computed tomography department ,30 subjects exposed from x_ray department and 30 subjects unexposed from laboratory department in the same hospitals.

The method of the study is taking unstimulated saliva sample from the subjects and oral health measure.

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Key information

Conditions

Salivary Redox Biomarkers and Oral Health

Age range

30 year–40 year

Sex eligibility

Male

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male, 30_40 years ,no history of systemic disease, no medical treatment taken at least 3 months before sampling and the subjects are exposed to radiation 5_ 10 years

Exclusion criteria

  • subjects with medical history , subjects are taken medications during last 3 months , the subjects are exposed to radiation less than 5 years or more than 10 years

Treatment and study plan

Salivary redox biomarkers

Radiation

Salivary redox biomarkers

Primary outcomes

  1. oral health status

    Time frame: Baseline: the subjects must be fasting. up to two hours saliva collection

    Changes in the clinical periodontal parameter (Plaque index ) To determine the patients' plaque index, their dental plaque thickness was evaluated by probing the mesial, distal, buccal, and palatal surfaces of all teeth using a Williams periodontal probe. The individual's plaque index was determined by summing the values obtained for each tooth and calculating the averages.Silness & Löe (Silness & Löe,1964) reference values were taken as a basis The Plaque Index (PI) scores each site on a 0 to 3 scale Score 0 : No plaque is in the area adjacent to the gingiva. Score 1: There is a plaque in the form of a thin film on the gingival margin. Score 2: There is a visible plaque in the gingival pocket and gingival margin. Score 3: There is a dense plaque in the gingival pocket and on the gingival margin.

Secondary outcomes

  1. Salivary Malondialdehyde biomarker

    Time frame: Baseline:saliva collection for malondialdehyde . up to two hours fasting for all subjects.

    Measure salivary malondialdehyde biomarker for all 90 subjects (computed tomography,x_ray and laboratory group) to see if the ionizing radiation effect on salivary Redox status in relation to oral health condition for workers in radiation field

  2. Salivary 8_ hydroxy_deoxyguanosine biomarker

    Time frame: Baseline:saliva collection for 8_hydroxy_deoxyguanosine .up to two hours fasting for all subjects.

    Measure salivary 8_hydroxy_deoxyguanosine biomarker for all 90 subjects (computed tomography,x_ray and laboratory group) to see if the ionizing radiation effect on salivary Redox status in relation to oral health condition for workers in radiation field

  3. Salivary catalase biomarker

    Time frame: Baseline:saliva collection for catalase . up to two hours fasting for all subjects.

    Measure salivary catalase biomarker for all 90 subjects (computed tomography,x_ray and laboratory group) to see if the ionizing radiation effect on salivary Redox status in relation to oral health condition for workers in radiation field

Study contacts

Contact information is provided by the study sponsor or research team.

Jihan Munther Hussien, B.D.S

CONTACT

[email protected]

+9647719770649

Sponsors and collaborators

Lead sponsor

Al-Mustansiriyah University

Other

Registry information

Official study title

Salivary Redox Biomarkers in Relation to Oral Health Condition Among a Group of Ionizing Radiation Field Workers

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 13, 2025
Registry last updated
Jun 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.