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Completed

NCT Number: NCT01875575

Oral Glucose Stimulation in Normal-weight and Obese Volunteers

The objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in normal-weight and obese patients.

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Key information

Conditions

Endocrine System Diseases

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Basel

Basel, CH-4031, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy normal weight subjects with a body-mass index of 19.0-24.5 or healthy obese subjects with a body-mass index of > 30
  • Normal eating habits
  • Age 18-40 years
  • Stable body weight for at least three months

Exclusion criteria

  • Smoking
  • Substance abuse
  • Regular intake of medications (except for oral contraceptives)
  • Medical or psychiatric illness
  • Any abnormality detected during the screening procedure
  • history of gastrointestinal disorders
  • food allergies

Treatment and study plan

Placebo

Dietary Supplement

Glucose 25g

Dietary Supplement

Glucose 10g

Dietary Supplement

Primary outcomes

  1. Effect of different oral glucose loads on secretion of satiation hormones

    Time frame: 240min.

    Plasma concentrations of glucose, insulin, glucagon, ghrelin, GLP-1, PYY and CCK are measured

Secondary outcomes

  1. Effect of different oral glucose loads on gastric emptying

    Time frame: 240min.

    measured by C13 breath test

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Official study title

Oral Glucose in Normal-weight and Obese Volunteers

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Jun 12, 2013
Registry last updated
Jun 12, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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