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Completed

NCT Number: NCT03374878

Oral Contraceptive and Strength Training

Cross sectional study investigating the effect of strength training in users and non-users of oral contraceptives (OC) (2nd generation OC)

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Key information

Conditions

Healthy Behavior Motor Activity

Age range

18 year–30 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Aarhus University, Department for Public Health, Section for Sport Science

Aarhus, 8000, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18.5 - 30 years
  • BMI < 30

Exclusion criteria

  • Medicine influencing protein turnover
  • Surgery on the knee
  • Arthritis
  • Diabetes
  • Smoking
  • irregular menstruation (<24 days or >35 days cycles)
  • Non-users: not have used contraceptives for the last 3 months.
  • Unstable weight (+/- 5 kg within the last 6 months)
  • Regular training/exercise more than 2 hours/week for the last 6 months. Maximum 70 km of cycling transport/week.
  • Strength training >1time/month for the last 6 months.
  • Pregnancy
  • Diet og eating disorder
  • Can not read or understand danish

Treatment and study plan

no oral contraceptive and training

Other

10 weeks of training in a group of oral contraceptive users

oral contraceptive and training

Other

10 weeks of training in a group of users of oral contraceptives

Primary outcomes

  1. Muscle mass

    Time frame: Baseline + after 10 weeks of resistance training.

    Change in muscle mass determined by MRI scan of thigh muscle

Secondary outcomes

  1. Muscle fiber size

    Time frame: Baseline + after 10 weeks of resistance training.

    Change in muscle fiber cross sectional area measured by histology.

  2. Muscle strength

    Time frame: Baseline + after 10 weeks of resistance training.

    Change in isometric strength

  3. Blood values

    Time frame: Baseline + after 10 weeks of resistance training.

    Change in sex hormone profile measured by blood sample analysis

  4. Functionality

    Time frame: Baseline + after 10 weeks of resistance training.

    Change in jump performance by RSI (Reactive strength index) measures

  5. Fat free mass (FFM)

    Time frame: Baseline + after 10 weeks of resistance training.

    Change in FFM measured by dual energy x-ray absorptiometry (DXA) scan of whole body composition

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Official study title

E5 - Oral Contraceptive and Strength Training (2nd Generation)

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Dec 15, 2017
Registry last updated
Sep 25, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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