Oral and Systemic aMMP-8 in Periodontal Disease

Periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health. Matrix metalloproteinase (MMP)-8 is the major collagenase of periodontal tissue breakdown. The aim of the present study is to analyze active (aMMP-8) levels in gingival crevicular fluid (GCF), saliva and serum in the context of new criteria of gingivitis and stage 3 grade C periodontitis.

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Key information

Conditions

Periodontal Diseases Gingival Diseases Gingivitis Infections Mouth Diseases Periodontal Inflammation Periodontitis Stomatognathic Diseases

Age range

25 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Aydin Adnan Menderes University

Aydin, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

systemically healthy and non-smoker individuals aged 25 to 50 years
having ≥20 teeth present (except third molars)
individuals with periodontally healthy, gingivitis and stage 3 periodontitis diagnoses

Exclusion criteria

having any systemic disease
smoking
pregnancy or lactation
using antibiotic or any anti-inflammatory drug or any periodontal treatment within the past 6 months.

Treatment and study plan

biochemical analysis

Other

aMMP-8 is measured by immunofluorometric assay (IFMA).

Primary outcomes

Oral (GCF and saliva) and serum levels of aMMP-8 in periodontitis and gingivitis

Time frame: through study completion, an average of 4 months

aMMP-8 levels

Sponsors and collaborators

Lead sponsor

Aydin Adnan Menderes University

Other

Collaborators

Giresun University

Registry information

Official study title

Local And Systemic Levels of aMMP-8 in Gingivitis and Stage 3 Periodontitis

Important dates

Study start: 2020
Primary completion: 2020
Study completion: 2020
First posted: Feb 13, 2020
Registry last updated: Jul 14, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed