Oral and Perioral Herpes Simplex Virus Infection Type I in a Five-month-old Infant: A Case Report

A five-month-old healthy girl who presented with painful herpetic gingivostomatitis and perioral vesicles.

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Key information

Conditions

Herpes Simplex Virus Infection DNA Virus Infections Herpes Simplex Herpesviridae Infections Infections Mouth Diseases Skin Diseases Skin Diseases, Infectious Skin Diseases, Viral Skin and Connective Tissue Diseases Stomatitis Stomatitis, Herpetic Stomatognathic Diseases Virus Diseases

Sex eligibility

Female

Study type

Observational

Primary location

Princess Nourah Bint Abdulrahman University

Riyadh, Saudi Arabia

About this study

The investigators present the case of a five-month-old healthy girl who presented with painful herpetic gingivostomatitis and perioral vesicles. The investigators discuss the pathophysiology of primary herpes simplex virus infection and the effect of maternal antibodies on the infant's immune system. In addition, the investigators explain the diagnosis, management, and prognosis of herpes simplex virus infection in young infants.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Five-months-old infants or younger

Exclusion criteria

Six-months-old infants or older

Treatment and study plan

Diagnosis and treatment of the case

Diagnostic Test

The infant was transferred to a hospital for better management of her infection. She was immediately started on intravenous acyclovir (20 mg/kg/6 h/5 d) while acetaminophen suppositories (80 mg/8 h/5 d) were given to lower her body temperature. In addition, other palliative drugs, such as diphenhydramine syrup (12.5 mg/5 mL, 2.5 mL orally) once-a-night for five days, were given to ease the effort of drinking and to aid in achieving good sleep. Upon completion of five days of therapy, the patient showed complete recovery and was subsequently discharged from the hospital free from symptoms.

Primary outcomes

Health condition

Time frame: one week

Number of tests were performed and different drugs were administered

Sponsors and collaborators

Lead sponsor

Princess Nourah Bint Abdulrahman University

Other

Registry information

Important dates

Study start: 2017
Primary completion: 2017
Study completion: 2017
First posted: Jan 19, 2021
Registry last updated: Jan 19, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed