Optimum Platelet Inhibition After Coronary Bypass Surgery

To investigate the effect of different dosages of aspirin on platelet aggregation and to determine the possible mechanisms of aspirin resistance, we intend to compare the effects of low, medium dose aspirin with clopidogrel (an alternative antiplatelet agent) in patients after coronary artery bypass surgery.

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Key information

Conditions

Ischemic Heart Disease Cardiovascular Diseases Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Papworth Hospital

Cambridge, CB3 8RE, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

We intend to invite patients aged 18 to 80 proceeding to primary elective coronary artery bypass surgery, able to give informed consent.

Exclusion criteria

Preoperative exclusion criteria:

patients who are have not stopped aspirin 7 days prior to surgery
patients on concomitant NSAIDS
patients with a previous history platelet disorders, splenectomy or haematological disorders
patients with aspirin induced asthma
patients with any contraindications to aspirin (GI bleed)
patients who are on any medication that may result in a serious drug interaction with aspirin (warfarin)
Women of childbearing potential
Patients of less than 18 years
If informed consent cannot be obtained
If for any reason the consultant surgeon or anaesthetist deems it to be appropriate

Operative exclusion criteria:

Concomitant procedures

Postoperative exclusion criteria:

patients who receive platelet transfusion
patients who receive NSAIDS
requirement for intra aortic balloon pump support
failure of extubation within 24 hours

Treatment and study plan

Aspirin, Clopidogrel

Drug

Sponsors and collaborators

Lead sponsor

Papworth Hospital NHS Foundation Trust

Other Gov

Registry information

Official study title

Optimum Platelet Inhibition After Coronary Artery Bypass Surgery: A Randomised Trial Comparing Platelet Aggregation Using Low, Medium Dose Aspirin and Clopidogrel

Important dates

Study start: 2002
Primary completion: 2004
First posted: Dec 6, 2005
Registry last updated: Jan 22, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed