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OpenTrials
Completed

NCT Number: NCT05952960

Optimizing Open Label Placebo Rationales

A 3-arm randomized trial where all chronic pain patients will receive honest placebos, but the information about the placebos will differ between conditions. Outcomes are measured for 21 days and a qualitative survey will be conducted.

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Key information

Conditions

Chronic Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Rhode Island Hospital

Providence, Rhode Island, 02912, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • chronic pain
  • 18 years old
  • English speaking
  • have a smartphone or computer with video access
  • Taking prescription opioids for chronic pain
  • the chronic pain is concentrated into the patient's lower back.

Exclusion criteria

  • suspect an allergy to any placebo ingredient
  • problematic substance use
  • cancer diagnosis causing pain
  • anticipated change in opioid script during the study period.

Treatment and study plan

Placebo

Other

Open Label Placebo + Rationale

Primary outcomes

  1. Pain Reports

    Time frame: 21 days

    Brief Pain Inventory: Pain intensity and pain interference

Secondary outcomes

  1. Opioids

    Time frame: 21 Days

    Quantity of prescription opioids taken

Sponsors and collaborators

Lead sponsor

Rhode Island Hospital

Other

Registry information

Official study title

Optimizing Open Label Placebo Rationales for Chronic Pain

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jul 19, 2023
Registry last updated
Jul 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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