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Completed

NCT Number: NCT07360769

Optimizing Hemodialysis: How Low Dialysate Flow Alters Adequacy and Patient Recovery.

The goal of this clinical trial is to detect if lower dialysate flow rate can affect hemodialysis adequacy , dialysis recovery time and patients quality of life.

The main questions it aims to answer are:

does low dialysate flow affect hemodialysis adequacy? does green dialysis achievable without affecting hemodialysis adequacy? Researchers will compare hemodialysis session of high dialysate flow to that with low dialysate flow.

Participants will:

underwent hemodialysis for a week with low dialysate flow and another week with high dialysate flow.

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Key information

Conditions

End Stage Kidney Disease (ESRD) Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Failure, Chronic Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine Alexandria University

Alexandria, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ESKD patients more than or equal 18 years old, on maintenance HD thrice weekly for more than three months and each session lasts for 4 hours.
  • All patients will receive HD via an arterio-venous fistula.
  • All patients will receive HD via the same type of HD machine and the blood pump will be set at 300ml/min.
  • All patients will receive the same type of HD membranes and every effort will be made to achieve the dry weight of the patients.

Exclusion criteria

  • Critically ill and hospitalized ESKD patients.
  • Mentally disabled patients.
  • Patients with terminal malignancy or receiving chemotherapy.
  • Patients receiving immune suppression treatment.

Treatment and study plan

lower dialysate flow rate ( 300ml/min). then testing its effect on hemodialysis adequacy

Other

The aim of this study is to check whether change of dialysate flow from 500ml/min to 300ml/min has a significant impact on dialysis adequacy , dialysis recovery time and patient reported outcome measures in maintenance hemodialysis patients.

Primary outcomes

  1. The change of dialysate flow rate, for three successive conventional hemodialysis sessions, from 500ml/min to 300ml/min and its impact on hemodialysis adequacy that is assessed by urea reduction ratio (URR).

    Time frame: Two weeks

  2. The change of dialysate flow rate, for three successive conventional hemodialysis sessions, from 500ml/min to 300ml/min and its impact on hemodialysis adequacy that is assessed by and single-pool Kt/V (spKt/V) using the Daugirdas formula.

    Time frame: Two weeks

Secondary outcomes

  1. The effect of lowering dialysate flow rate from 500ml/min (milli per minute) to 300ml/min on dialysis recovery time (DRT) in minutes. Longer duration indicates lower dialysis adequacy.

    Time frame: two weeks

  2. The patients reported outcome measures that is assessed by palliative care Outcome Scale - Symptoms Renal (POS S renal). Each symptom takes a score from zero to four (0-4), high score indicates less efficient dialysis.

    Time frame: Tow weeks

Sponsors and collaborators

Lead sponsor

Alexandria University

Other

Registry information

Official study title

Low Dialysate Flow: Its Effect on Hemodialysis Adequacy, Dialysis Recovery Time and Patient Reported Outcome Measures.

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jan 22, 2026
Registry last updated
Jan 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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