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OpenTrials
Completed

NCT Number: NCT01882569

Optimization of Time-of-Flight Mass Cytometry (CyTOF) Analysis for Evaluation of Immune Changes Following Surgery

Surgical trauma triggers a massive inflammatory response. Over time, both the innate and adaptive branches of the immune system are affected by surgical trauma. The purpose of this study is to use a single cell flow cytometry approach to characterize the cellular and molecular mechanisms involved in the inflammatory response to surgical trauma.

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Key information

Conditions

Surgical Trauma

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Stanford University Hospital

Stanford, California, 94305, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Ages 18 - 90
  • Men and women
  • Undergo back surgery

Exclusion criteria

  • Any systemic disease that might compromise the immune system (e.g. lupus)
  • Current diagnosis of cancer
  • Any condition that, in the opinion of the investigator, might compromise the integrity of the study or safety of the participant.
  • Unwilling to sign informed consent

Treatment and study plan

Primary outcomes

  1. Numerical (cell frequencies) and functional (phosphorylation of signaling proteins and transcription factors) changes of all circulating immune cells

    Time frame: Immediately before to surgery, 1 hour after surgery, 24 hours after surgery, and day of hospital discharge

    This is an exploratory study.

Sponsors and collaborators

Lead sponsor

Martin Angst

Other

Registry information

Official study title

Detection of Immune Changes as a Result of Surgical Trauma in Human Back Surgery Subjects: Optimization of CyTOF Analysis

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Jun 20, 2013
Registry last updated
May 4, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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