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OpenTrials
Completed

NCT Number: NCT03438981

Optimization of PK/PD Target Attainment for Ceftriaxone in Critically Ill Patients With Community-acquired Pneumonia.

WP2.1. PK/PD target attainment Plasma exposure ELF exposure WP2.2. Predictive dosing algorithm WP2.3. ECMO subset

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Key information

Conditions

Pharmacokinetics Blood Protein Disorders Critical Illness Disease Attributes Hematologic Diseases Hemic and Lymphatic Diseases Hypoalbuminemia Hypoproteinemia Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

UZLeuven

Leuven, 3000, Belgium

About this study

First, the investigators will document exposure to ceftriaxone in plasma and epithelial lining fluid.

Second, the investigators will try to identify risk factors for not attaining PK/PD target. Based on significant predictors for target non attainment a predictive dosing algorithm will be constructed.

Finally in a small subset of ECMO patients PK exposure will be explored.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pneumonia
  • Admitted to an ICU ward
  • Treated with ceftriaxone

Exclusion criteria

  • Pregnancy
  • DNR code 2-3
  • Renal replacement therapy

Treatment and study plan

Primary outcomes

  1. Risk factors for target non attainment

    Time frame: on day of sampling

    risk factors will be assessed by comparing patients who attain target vs. those who don't

Sponsors and collaborators

Lead sponsor

Universitaire Ziekenhuizen KU Leuven

Other

Collaborators

  • KU Leuven

Registry information

Official study title

Impact op Capillary Leak and Hypoalbuminemia on PK/PD of Ceftriaxone in Critically Ill Patients With Overwhelming Pneumonia

Important dates

Study start
2013
Primary completion
2018
Study completion
2019
First posted
Feb 20, 2018
Registry last updated
Apr 28, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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