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NCT Number: NCT05929144

Optimization of MRI Sequences Used in the Study of Neurodegenerative Diseases

The Inserm NeuroPresage team has been using MRI for more than 20 years in the study of normal ageing and memory pathologies to further the understanding and the characterization of early diagnosis and the cerebral substrates of cognitive deficits in patients, particularly in the context of neurodegenerative diseases.

Two years ago, a new 3T MRI camera was installed at the Cyceron centre. It is more efficient and should make it possible to obtain better quality images and/or to reduce the time required to acquire these images.

In this context, it seems important to test the different sequences that we classically use in our studies, or that we plan to implement in our next studies (learning and text retrieval fMRI task), in order to optimize them, with a view to integrating them in our future studies.

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Key information

Conditions

Memory Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

GIP Cyceron

Caen, 14000, France

Location status: Recruiting

Location contact

Géraldine Poisnel, PhD

CONTACT

[email protected]

0231470206

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers of legal age
  • Affiliation with a social security scheme or beneficiary of such a scheme
  • Signing of the protocol informed consent
  • For women of childbearing age or capacity, a urine pregnancy test before inclusion

Exclusion criteria

  • Protected persons in accordance with articles L. 1121-5 to L.1121-8 of the Public Health Code: protected adults, pregnant and nursing women
  • Presence of contraindications to MRI examination without contrast agents injection
  • Presence of a chronic neurological or psychiatric condition (including substance use disorder)
  • History of brain disease (vascular, degenerative, malformative, tumour, or head trauma with loss of consciousness for more than one hour)
  • Current or recent use of medications that may interfere with imaging (psychotropic drugs, antihistamines with anticholinergic action, antiparkinsonian drugs, benzodiazepines including muscle relaxants, long-term steroidal anti-inflammatory drugs, antiepileptic drugs, central painkillers)

Treatment and study plan

MRI sequences testing

Other

Testing different MRI sequences in order to optimize them

Primary outcomes

  1. Optimization of MRI sequences

    Time frame: During MRI sessions

    TR, TE, Flip Angle, asset phase, asset slice parameters

Study contacts

Contact information is provided by the study sponsor or research team.

Géraldine Poisnel, PhD

CONTACT

[email protected]

0231470206

Sponsors and collaborators

Lead sponsor

University Hospital, Caen

Other

Registry information

Official study title

Optimization of MRI Sequences Used in the Study of Neurodegenerative Diseases at Inserm U1237 NeuroPresage Team, Cyceron Center in Caen

Acronym: IRMtests

Important dates

Study start
2023
Primary completion
2028
Study completion
2028
First posted
Jul 3, 2023
Registry last updated
Jul 3, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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