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NCT Number: NCT05618990

OPTIMIZATION of ADVANCED MR SEQUENCES

This monocentric methodological study aims at optimizing advanced MR sequences for image quality (reduced artefacts, signal to noise ratio, acquisition time, stability of quantitative measurements) on a new MR unit dedicated to research in clinical and cognitive neuroscience.

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Key information

Conditions

Neurosciences Brain Diseases Brain Neoplasms Brain Tumor Cardiovascular Diseases Central Nervous System Diseases Central Nervous System Neoplasms Cerebrovascular Disorders MRI Mental Disorders Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

OPPENHEIM Catherine

Paris, 75014, France

Location status: Recruiting

Location contact

OPPENHEIM Catherine

CONTACT

[email protected]

OPPENHEIM Catherine, Doctor

PRINCIPAL_INVESTIGATOR

About this study

Primary goal : Optimization of MR protocols and validation of acquisition parameters of advanced MR sequences on healthy volunteers or patients on a new 3T MR unit dedicated to research in neurosciences.

Secondary goals

  • Perform acquisitions to validate the feasibility of research MR protocols (pilot subjects)
  • reproducibility studies

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 ans
  • Covered by social security
  • For women in age of procreation, under efficient contraception
  • Written consent

Exclusion criteria

  • Any MR contraindication
  • Claustrophobia
  • Pregnancy
  • Under judiciary protection

Treatment and study plan

Primary outcomes

  1. MR sequences optimization

    Time frame: 72 months

    Optimization of MR protocols and validation of acquisition parameters of advanced MR sequences on healthy volunteers or patients on a new 3T MR unit dedicated to research in neurosciences. Outcome measures depend on each pulse optimized sequence (signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).

Secondary outcomes

  1. Reproducibility studies

    Time frame: 72 months

    Reproducibility studies (quantitative parameters, effect of denoising ...). Outcome measures depend on each pulse optimized sequence (artifacts, signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).

  2. Pilot studies

    Time frame: 72 months

    Feasibility studies in cognitive neurosciences. Outcome measures depend on each MR protocol (artifacts, signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).

Study contacts

Contact information is provided by the study sponsor or research team.

Khaoussou SYLLA

CONTACT

[email protected]

01 45 65 76 78 ext. 0033

Viviane AWASSI

CONTACT

[email protected]

01 45 65 84 86 ext. 0033

Sponsors and collaborators

Lead sponsor

Centre Hospitalier St Anne

Other

Registry information

Official study title

OPTIMIZATION of AVANCED MR SEQUENCES for BRAIN STUDIES in VOLUNTEERS (HEALTHY and PATIENTS)

Acronym: OPT-IRM

Important dates

Study start
2019
Primary completion
2025
Study completion
2025
First posted
Nov 16, 2022
Registry last updated
Jul 10, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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