OPTImisation and Standardization of CIRCulating Cell-free DNA Ex-traction Protocols in a Diagnostic Setting

comparison of blood collection tubes and cell-free DNA extraction to evaluate the best possible combination to obtain high quantity and quality cell-free DNA sample for NGS analyses

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Key information

Conditions

Healthy

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

at least 18 years
no serious condition

Exclusion criteria

younger than 18 years
serious health condition that leads to higher cfDNA content in blood

Treatment and study plan

Primary outcomes

cfDNA quantity

Time frame: Baseline, at enrollment

we will assess the quantities in ng/µl of cell-free DNA extracted from plasma
cfDNA quality

Time frame: Baseline, at enrollment

we will assess the fragments length in nucleotides using TermoFisher's Tapestation from the extracted plasma cell-free DNA

Sponsors and collaborators

Lead sponsor

University Hospital Tuebingen

Other

Registry information

Acronym: OPTICIRC

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Mar 11, 2025
Registry last updated: Mar 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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