Optimisation and Quantification of Contrast Enhanced Computed Tomography Myocardial Fibrosis Imaging

Detecting scarred heart muscle is important to diagnose and treat of a wide variety of heart conditions. Magnetic resonance imaging (MRI) can assess scarred heart muscle but it is time consuming, contraindicated for some patients and not tolerated by others. Computed tomography (CT) imaging has the potential to provide a rapid comprehensive assessment of the heart. This study will assess CT imaging of the heart muscle of patients who have previously undergone MRI of their heart. Using a state of the art CT scanner the investigators will develop a low radiation dose protocol to identify scarred heart muscle. The investigators will use and develop software techniques to analyse these images. This will enable us to develop a new way to identify and measure scarred heart muscle that will benefit patients with heart disease.

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Key information

Conditions

Myocardial Infarction Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

40 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Presence of late enhancement on magnetic resonance imaging

Exclusion criteria

age less than 40
inability or unwillingness to undergo CT
renal failure (serum creatinine >200 umol/l or estimated glomerular filtration rate <30 ml/min)
hepatic failure
allergy to iodinated contrast
pregnancy
breast feeding
inability to undergo informed consent
fast atrial fibrillation

Treatment and study plan

Computed tomography late enhancement imaging

Radiation

Primary outcomes

Myocardial late enhancement

Time frame: Immediate

The amount of myocardial late enhancement measured on computed tomography as compared to magnetic resonance imaging.

Sponsors and collaborators

Lead sponsor

University of Edinburgh

Other

Registry information

Official study title

Optimisation and Quantification of Contrast Enhanced Computed Tomography

Important dates

Study start: 2013
Primary completion: 2015
Study completion: 2023
First posted: Feb 18, 2015
Registry last updated: Jun 27, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed