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Completed

NCT Number: NCT06141668

Optimal Stimulation Parameters to Disrupt Epileptiform Activity

Open-loop electrical stimulation has been found to reduce spike activity and seizures, but determining the optimal parameters to achieve these effects requires a brute force trial-and-error approach that relies on subjective physician discretion. We will compare the performance of stimulation parameters identified in rodent models to the recommended parameters for neuromodulation used in clinical practice.

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Key information

Conditions

Refractory Epilepsy Brain Diseases Central Nervous System Diseases Drug Resistant Epilepsy Epilepsy Nervous System Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Undergoing intracranial EEG investigation at Massachusetts General Hospital during presurgical epilepsy evaluation

Exclusion criteria

  • Baseline spike ripple rate < 0.5/min.

Treatment and study plan

Neurostimulation

Other

Electrical stimulation

Primary outcomes

  1. Spike ripple rate

    Time frame: 1-3 hours

    Spike ripple rate (count per minute)

Secondary outcomes

  1. Spike rate

    Time frame: 1-3 hours

    Spike rate (count per minute)

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Collaborators

  • Boston University
  • National Institute of Neurological Disorders and Stroke (NINDS)

Registry information

Official study title

Optimal Stimulation Parameters for Spike-ripple Disruption in Patients Undergoing Invasive Monitoring

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Nov 21, 2023
Registry last updated
Apr 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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