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NCT Number: NCT07354347

Optimal Settings for Anti Tachycardia Pacing (ATP) on ICD

This is a pragmatic, two-group, cluster randomized trial designed to compare strategies for the Anti Tachycardia Pacing (ATP)-setting in the ventricular tachyarrhythmias (VT) zone when implanting a new implantable cardioverter defibrillator (ICD) in patients with heart disease in hospitals in Denmark.

The strategies are: "Burst" or "Ramp" after 1. ATP (which is always burst) in VT zone. VT zone is defined between 180-249 (up to 269 in special cases) heartbeats per minute.

The ICD will give either:

Burst: The ICD is programmed to give ATP with 4 bursts. Or Ramp: The ICD is programmed to give ATP with 1 burst and 3 ramps.

The participating hospitals will be assigned to one of two intervention strategies for periods of 4-months. The given intervention will follow the patient/ICD throughout the life time of the ICD, but with the possibility to reprogram at any time (intention to treat).

It is calculated that the study needs a total of 398 events (second to fourth ATP), which is estimated to require 3980 implanted ICDs. The participants will be followed until the end of the ICD life, which is estimated to be around 10 years.

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Key information

Conditions

Heart Disease Arrhythmias, Cardiac Cardiac Conduction System Disease Cardiovascular Diseases Heart Diseases Heart Failure Heart Rhythm Disorders Implantable Cardioverter Defibrillator (ICD) Pathologic Processes Pathological Conditions, Signs and Symptoms Tachycardia Tachycardia, Ventricular Ventricular Tachyarrhythmias

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ICD implantation for primary or secondary prophylactic indication

Exclusion criteria

  • None
  • Patients can actively opt out of participation in the study

Treatment and study plan

Burst

Other

ATP with 4 burst

Ramp

Other

ATP with 1 Burst + 3 Ramp

Primary outcomes

  1. Arrhythmia cessation

    Time frame: The lifetime of the ICD, estimated 10 years

    The ability of the given ATP protocol to stop the ventricular arrhythmia

Secondary outcomes

  1. Defibrillation

    Time frame: The lifetime of the ICD, estimated 10 years

    Arrhythmia accelerates resulting in defibrillation/shock therapy

Study contacts

Contact information is provided by the study sponsor or research team.

Bo G Winkel, MD, PhD

CONTACT

[email protected]

+4535459759

Sponsors and collaborators

Lead sponsor

Rigshospitalet, Denmark

Other

Collaborators

  • The Novo Nordic Foundation

Registry information

Official study title

Optimal ATP Settings in the VT Zone for New Implantable Cardioverter Defibrillator (ICD) Implantation (DAN-ATP)

Acronym: DAN-ATP

Important dates

Study start
2026
Primary completion
2041
Study completion
2041
First posted
Jan 21, 2026
Registry last updated
Jan 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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