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Completed

NCT Number: NCT01083953

Optimal End-Tidal (ET) Sevoflurane and Desflurane Concentration for Extubation of Supreme Laryngeal Mask Airway (LMA) in Adults

The purpose of this study is to determine the optimal volatile anaesthetic (sevoflurane and desflurane) to remove a Supreme LMA in adults in which there is minimal airway response.

Null hypothesis: there is no significant difference between the optimal end tidal concentration of sevoflurane and desflurane for Supreme LMA removal.

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Key information

Age range

18 year–49 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Malaya Medical Centre

Kuala Lumpur, 59100, Malaysia

About this study

The manufactures' instructions for removal of the LMA recommend waiting until protective reflexes have returned. However, the appropriate timing for removal remains controversial. A more frequent incidence of airway hyperreactivity and complications has been reported by some studies when the LMA was removed in the awake state versus the anesthetized state. Techniques that reduce the time from LMA removal to the return of protective airway reflexes would minimize the risk of aspiration, contamination, or airway obstruction.

With increasingly common use of Supreme LMA in anaesthetic practice, a safe and suitable depth for removal of the Supreme LMA requires research.

Thus the determination of the optimal end-tidal concentration of commonly used volatile agents ie. Sevoflurane and Desflurane for Supreme LMA removal requires research, both for patient safety and minimising anaesthetic costs in dealing with airway complications.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA 1-2 patients
  • Age 18 - 49 years old
  • Elective surgery of short duration ( < 2 hours ) which require local anaesthetic infiltration

Exclusion criteria

  • Upper respiratory tract symptoms in the previous 10 days
  • Risk of gastric oesophageal reflux or regurgitation
  • Known or predicted difficult airway
  • Poor dentition with high risk of damage
  • BMI > 30 kg/m2
  • Refusing to participate

Treatment and study plan

Sevoflurane

Drug

Comparing the optimal end-tidal concentration sevoflurane and desflurane for LMA extubation

Desflurane

Drug

Comparing the optimal end-tidal concentration sevoflurane and desflurane for LMA extubation

Primary outcomes

  1. Optimal end tidal concentration of sevoflurane/ desflurane

    Time frame: 6 months

Secondary outcomes

  1. presence of airway response

    Time frame: 10 mins after surgery

Sponsors and collaborators

Lead sponsor

University of Malaya

Other

Collaborators

  • Malaysian Society of Anaesthesiologists

Registry information

Official study title

Optimal End-Tidal Concentration of Sevoflurane and Desflurane for Removal of Supreme Laryngeal Mask Airway in Anaesthetized Adults

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Mar 10, 2010
Registry last updated
Dec 3, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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