Optical Coherence Tomography and Optic Neuritis Not Related to Multiple Sclerosis

The visual prognosis of optic neuritis not related to multiple sclerosis is unknown, both in terms of functional recovery and evolution.

This prospective cohort study aim to assess the ophthalmological evolution of patients presenting an episode of optic neuritis (NO) not related to a multiple sclerosis or to a clinically isolated syndrome.

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Key information

Conditions

Optic Neuritis Cranial Nerve Diseases Eye Diseases Nervous System Diseases Optic Nerve Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondation A. de Rothschild

Paris, 75019, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

First onset of an optic neuritis lasting for less than 1 month
With a brain MRI that does not meet the MS criteria

Exclusion criteria

Contra-indication to MRI
Pregnant or lactating woman
History of known ipsilateral optic neuritis
Ophthalmologic comorbidity in the ipsilateral eye that may interfere with the interpretation of the examinations

Treatment and study plan

Primary outcomes

Visual acuity (ETDRS scale)

Time frame: 1 year

Evolution over 1 year of the ophthalmological parameters of patients treated for an episode of optic neuritis not related to multiple sclerosis or a clinically isolated syndrome
Thickness of the layers of the retina with Optical Coherent Tomography(OCT),

Time frame: 1 year
Standard Humphrey Visual Field Test

Time frame: 1 year

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Official study title

Evaluation and Follow-up of Optic Neuritis Not Related to Multiple Sclerosis

Acronym: OCTON2

Important dates

Study start: 2020
Primary completion: 2024
Study completion: 2024
First posted: May 24, 2019
Registry last updated: Jun 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed