Optical Biopsy for Peritoneal Nodules in Colorectal Patients

Peritoneal metastasis is a common metastatic site in colorectal cancer patients, and those with peritoneal metastasis often have a poor prognosis. During surgery, peritoneal metastasis is confirmed pathologically through resection sample, but frozen section pathology can take up to 30 minutes, which is a significant amount of time.

To address this issue, we suggest utilizing probed-based confocal laser endoscopy (pCLE), a novel endoscopic adjunct that enables real-time in vivo histological examination of mucosal surfaces. By using intravenous fluorescent agents, pCLE highlights certain mucosal elements that facilitate an optical biopsy in real time.

By providing a promising optical biopsy, CLE has the potential to enable in situ, real-time, and in vivo diagnosis of colorectal cancer patients with peritoneal nodules during surgery.

Inclusion criteria

• Age from over 18 to under 85 years
• American Society of Anesthesiology (ASA) score class I,II,or III
• Colorectal cancer
• Patients who be about to undergo surgical treatment
• Written informed consent

Exclusion criteria

• Pregnant or lactating women
• Acute renal insufficiency or stage II to IV chronic renal insufficiency
• Patients with severe liver damage
• Asthma patients or patients with allergic constitution