Optic Nerve Head Strain as Biomarker for Glaucoma

The investigators will test the hypothesis that images of the optic nerve head taken a 2 different eye pressures will yield strain estimates that are predictive of the course of glaucoma.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Glaucoma, Open-Angle Eye Diseases Glaucoma Ocular Hypertension

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Johns Hopkins University

Baltimore, Maryland, 21287, United States

About this study

Existing glaucoma patients and suitable control adults will be imaged with an FDA-approved optical coherence tomography instrument. Those who are imaged at 2 different eye pressures will generate biomechanical strain estimates. These will be compared to visual field and retinal nerve fiber layer measurements over time. The investigators expect that baseline strain and their changes over time will be associated with progression rate of glaucoma damage, providing a biomarker for susceptibility.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Existing glaucoma patients of Johns Hopkins

Exclusion criteria

Inability to perform imaging
illiterate
hearing impaired
non-English speakers

Treatment and study plan

Images of eye at 2 eye pressures

Device

subject images of the eye's optic nerve head are studied

Primary outcomes

Optic nerve head mechanical strain compared to visual field change over time

Time frame: Approximately 3 years

Strains measured at baseline are tested for association with glaucoma course

Sponsors and collaborators

Lead sponsor

Johns Hopkins University

Other

Collaborators

National Eye Institute (NEI)

Registry information

Important dates

Study start: 2024
Primary completion: 2028
Study completion: 2028
First posted: Feb 5, 2024
Registry last updated: Jun 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Active, Not Recruiting