Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery

In the present study, the primary aim was to evaluate if oxycodone-naloxone combination compared to oxycodone reduced opioid induced constipation in patients with or without chronic opioid treatment undergoing spine surgery.

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Key information

Conditions

Constipation Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Kuopio University Hospital

Kuopio, Northern Savonia, 70029, Finland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

BMI 17 - 35 kg/m2
elective spine surgery
informed consent obtained

Exclusion criteria

allergy to the used drugs
other contraindication to oxycodone medication
no informed consent

Treatment and study plan

oxycodone-naloxone

Drug

Oxycodone

Drug

Primary outcomes

opioid induced constipation

Time frame: from the surgery up to 21 days

Opioid induced constipation was assessed with bowel function index

Sponsors and collaborators

Lead sponsor

Kuopio University Hospital

Other

Registry information

Acronym: oksineukir

Important dates

Study start: 2012
Primary completion: 2014
Study completion: 2014
First posted: Oct 12, 2015
Registry last updated: Oct 12, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed