Open Label Phase 1 Pharmacokinetics and Tolerability Study of Single TAB08 Administration in Healthy Volunteers

Inclusion criteria

• Adult man aged from 18 to 40 years, who agreed to use adequate contraception.
• Body mass is at least 60 kg and BMI is within 20-27
• Volunteer is in good physical and mental health, as per his medical history and assessment results
• Volunteer's laboratory values are normal (or not clinically significant as per Investigator discretion) at screening, including baseline cytokines levels as per RESTORE test results
• Volunteer has signed the informed concent.

Exclusion criteria

• Any chronic or relapsing illness in the medical history
• Any abnormal assessment or laboratory result at screening, which is clinically significant as per Investigator discretion
• Active tuberculosis at the time of screening
• Any acute illness at the time of study enrollment
• Any blood donation within 4 weeks before Study Day 1
• Positive result for HBsAG, Hepatitis C, HIV
• Continuous use af any medications
• Use of any medications within 72 hours before study drug infusion
• Use of an investigational treatment within 4 weeks before screening, or within a period of 5 half-lives of the investigational treatment, whichever is longer
• High inflammatory cytokines levels as per RESTORE test results after ex vivo PBMC testing