Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06704061

Online Yoga vs Acceptance and Commitment Therapy for Treating Chronic Musculoskeletal Pain

This study will compare online yoga with Acceptance and Commitment Therapy (ACT), an established treatment for chronic pain. We will compare the efficacy of the two treatments for reducing chronic musculoskeletal pain in veterans.

Recruiting

Interested in participating?

Request Info

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Palo Alto VA Medical Center

Palo Alto, California, 94304, United States

Location status: Recruiting

Location contact

Annie Lau, BA

CONTACT

[email protected]

6503748516

Dave Clark, MD, PhD

SUB_INVESTIGATOR

Elizabeth Walker, MSPT

SUB_INVESTIGATOR

Jessica Lohnberg, PhD

SUB_INVESTIGATOR

Julie Wetherell, PhD

SUB_INVESTIGATOR

Louise Mahoney, MS

SUB_INVESTIGATOR

Peter Bayley, PhD

CONTACT

[email protected]

650-493-5000 ext. 68653

Peter Bayley, PhD

PRINCIPAL_INVESTIGATOR

Santiago Allende, PsyD

SUB_INVESTIGATOR

About this study

This study will test if online yoga is not inferior than ACT for treating chronic pain in veterans. Participants will be randomly assigned to receive either online yoga instruction or ACT, once a week for 12 weeks in an online group class. They will complete self-report questionnaires about their experience of chronic pain. There will be a 6-month follow up period, during which the research team will check in with the participant to record any adverse events and maintain study contact.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Veteran of the United States Armed Forces ≥ 18 years old
  • Chronic pain > 6 months related to at least one musculoskeletal pain-related diagnosis indicated by an ICD-9 or -10 code
  • Minimum pain intensity at screening ≥4 on a 0-10 using the Defense and Veterans Pain Rating Scale (DVPRS)
  • Not begun new pain treatments or medications in the past month
  • Stable medication regimen for at least 4 weeks prior to entry to the study
  • English literacy
  • Internet connection at home

Exclusion criteria

  • Participation in another clinical trial, unless given prior authorization from both our research team and that of the other study
  • Back surgery within the last 12 months
  • Back pain potentially attributed to a specific known condition
  • Baseline pain <4 or ≥9 on a 0-10 Numeric Rating Scale
  • Unstable, serious coexisting medical illness, mental illness or psychiatric conditions
  • Attended or practiced yoga ≥ 1 x in the past 12 months
  • Current suicidal intent or plan
  • Has received ACT in the past

Treatment and study plan

Yoga

Behavioral

A 12-week online yoga course designed to treat pain.

Acceptance and Commitment Therapy (ACT)

Behavioral

A 12-week behavioral therapy course designed to treat pain.

Primary outcomes

  1. Pain Interference (Brief Pain Inventory-Short Form)

    Time frame: Baseline, End-of-treatment at 12 weeks, and 6 months after treatment

    The degree to which pain impacts mood, walking and other daily activities, as measured by the Pain Interference Scale of the Brief Pain Inventory - Short Form (BPI-SF). The BPI-SF assesses intensity and impact of pain on functioning on a 0-10 rating scale, with higher scores indicating greater degree of interference.

Secondary outcomes

  1. Depression (BDI-II)

    Time frame: Baseline, End-of-treatment at 12 weeks, and 6 months after treatment

    Symptoms of depression as measured by the Beck Depression Inventory (BDI-II). The BDI-II is comprised of 21 self-report questions, scored on a 0-3 scale, with higher scores indicating more depressive symptoms.

  2. Sleep (Pittsburgh Sleep Quality Index)

    Time frame: Baseline, End-of-treatment at 12 weeks, and 6 months after treatment

    Sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI). The PSQI is a a self-rated questionnaire that assesses sleep quality and disturbances over a 1-month interval.

Study contacts

Contact information is provided by the study sponsor or research team.

Peter Bayley, PhD

CONTACT

[email protected]

650-493-5000 ext. 68653

Sponsors and collaborators

Lead sponsor

Palo Alto Veterans Institute for Research

Other

Registry information

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Nov 25, 2024
Registry last updated
Jan 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.