Online Exposure Therapy for Obsessive-Compulsive Disorder (OCD) Study

The overarching goal of this protocol is to investigate mechanisms that influence symptom outcomes of exposure and response prevention (ERP) therapy for OCD. Mechanisms may include affective processes, learning factors, cognitive factors, or other constructs that could influence treatment outcomes. The study team will conduct this research within the context of an effective online treatment for OCD called OCD-NET. OCD-NET is bibliotherapy with coaching and its content is reflective of standard care for OCD.

Completed

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Key information

Conditions

Obsessive-Compulsive Disorder Anxiety Disorders Mental Disorders

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Miami

Miami, Florida, 33146, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

English-speaking
Located within the United States
18-90 years old
Able to provide consent
Current diagnosis of OCD as assessed by clinical interview

Exclusion criteria

Adults unable to consent
Individuals who are not yet adults (infants, children, teenagers)
Participants currently located outside of the United States
Prisoners
Participants with hoarding as the primary OCD symptom
Severe mental illness (e.g. schizophrenia, substance abuse); organic brain syndrome; or serious, current suicidal/homicidal ideation (based on phone screening or initial assessment)
Concurrent enrollment in another psychotherapy treatment
Participants taking psychotropic medication may be excluded if:

They have started a brand new psychotropic medication within the last 12 weeks
They have changed the dose of their psychotropic medication within the last 4 weeks
They anticipate that they cannot maintain the current dose of their psychotropic medication for the duration of the study
Participants may be excluded if they have any cognitive or physical impairments that would interfere with their participation (e.g., significant head injury, cognitive disability, dementia).

Treatment and study plan

OCD-NET

Behavioral

OCD-NET is bibliotherapy with coaching and its content is reflective of standard care for OCD. OCD-NET is a self-paced intervention that participants complete entirely online with the support of an assigned individual therapist. Most participants complete this treatment in up to twelve weeks. On average, participants are expected to spend between one to five hours per week during the first half of treatment. In the second half of treatment when participants begin regular exposure and response prevention (ERP) exercises, participants are expected to spend about one hour per day.

Primary outcomes

Change in OCD Symptoms Measured by Yale-Brown Obsessive Compulsive Scale-Second Edition (YBOCS-II)

Time frame: Baseline, up to 12 months (end of treatment)

YBOCS-II scores range from 0-50, and higher scores indicate more severe illness

Sponsors and collaborators

Lead sponsor

University of Miami

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Jun 24, 2024
Registry last updated: Aug 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed