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Completed

NCT Number: NCT04216836

One Week of Magnesium Supplementation Lowers IL-6, Perceived Pain and Increases Post Exercise Blood Glucose in Response to Downhill Running

This study investigated the effect of magnesium supplementation on exercise performance and functional recovery in recreational endurance athletes in conjunction with measures of blood glucose, lactate, IL-6 and sIL-6R.

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Key information

Conditions

Magnesium Deficiency Deficiency Diseases Malnutrition Neurologic Manifestations Nutrition Disorders Nutritional and Metabolic Diseases Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of Worcester

Worcester, Worcestershire, WR1 3AS, United Kingdom

About this study

Magnesium status can directly affect circulating glucose concentrations both during and post exercise. In addition, magnesium supplementation has been shown to reduce circulating IL-6 concentrations post exercise in humans. It is conceivable that such observations are linked through the role of IL-6 in glucose regulation, possibly in combination with sIL-6R. Together, magnesium intake may have the potential to effect exercise performance and recovery through glucose availability. This in turn may be connected to the production of IL-6 and sIL-6R which have been established to influence exercise fatigue and perception of pain (muscle soreness).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Regular recreational runner, running around 3 times per week
  • Capable of running 10 km in ~ 40 minutes.

Exclusion criteria

  • Any signs or symptoms of cardiovascular issues.
  • Any recent form of injury or illness.
  • Currently, or in the last 3 months, have consumed multivitamin supplements
  • Currently, or in the last 3 months, have consumed anti-inflammatory medications.

Treatment and study plan

Magnesium oxide

Dietary Supplement

Magnesium capsule

Placebo

Dietary Supplement

Cornflour capsule manufactured to mimic the 166.6 mg magnesium capsule.

Primary outcomes

  1. Downhill 10 km treadmill time trial performance

    Time frame: 1 day

    Maximal 10 km time trial performance on a treadmill

  2. 24 hr post exercise maximal force testing of the dominant leg on the isokinetic dynamometer

    Time frame: 1 day

    Maximal force produced from the dominant leg (eccentric and concentric) on an isokinetic dynamometer.

Secondary outcomes

  1. Glucose

    Time frame: up to 2 days

    Capillary blood samples at rest, during, immediately post, 1 hr post and 24 hrs post 10 km downhill time-trial. A Biosen analyser was used to analyse glucose concentrations.

  2. Interleukin-6

    Time frame: up to 2 days

    Venous blood samples at rest, immediately post, 1hr post and 24 hrs 10 km downhill time trial. Enzyme-linked immunosorbent assays were used to analyse interleukin-6.

  3. Soluble interleukin-6 receptor

    Time frame: up to 2 days

    Venous blood samples at rest, immediately post, 1hr post and 24 hrs 10 km downhill time trial. Enzyme-linked immunosorbent assays were used to analyse soluble interleukin-6.

  4. Perceived muscle soreness

    Time frame: up to 4 days

    A 10cm visual analogue scale was used to assess perceived muscle soreness, the scale started at 0 (no pain) and finished at 10 (unbearable pain)

  5. Lactate

    Time frame: up to 2 days

    Capillary blood samples at rest, during, immediately post, 1 hr post and 24 hrs post 10 km downhill time-trial. A Biosen analyser was used to analyse lactate concentrations.

  6. Creatine kinase

    Time frame: up to 2 days

    Venous blood samples at rest, immediately post, 1hr post and 24 hrs 10 km downhill time trial. A Reflotron analyser was used to analyse creatine kinase concentrations.

Sponsors and collaborators

Lead sponsor

University of Worcester

Other

Collaborators

  • Beijing Sport University
  • Coventry University

Registry information

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Jan 3, 2020
Registry last updated
Jan 3, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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