One-stop Evaluation of Hypertrophic Cardiomyopathy in Cardiac Magnetic Resonance

This is a multi-center, observational study aiming to establish a precision diagnosis scheme and multi-dimensional risk prediction models for Hypertrophic Cardiomyopathy (HCM). The study plans to enroll 10000 adult HCM patients. It will integrate genetic testing, advanced cardiac imaging (echocardiography and cardiac magnetic resonance), and biomarker analysis to develop early diagnosis, differential diagnosis, and new risk prediction models for sudden cardiac death (SCD) and heart failure in HCM patients. Participants will undergo baseline assessments and be followed up every six months for up to 3 years to track clinical outcomes. This study is non-interventional and does not involve any investigational drugs or devices.

Enrolling by Invitation

Interested in participating?

Request Info

Key information

Conditions

Hypertrophic Cardiomyopathy (HCM) Aortic Stenosis, Subvalvular Aortic Valve Disease Aortic Valve Stenosis Cardiomyopathies Cardiomyopathy, Hypertrophic Cardiovascular Diseases Disease Heart Diseases Heart Valve Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

A maximal left ventricular wall thickness of ≥ 12 mm in any segment at end-diastole, as measured by echocardiography or Cardiac Magnetic Resonance (CMR)

Exclusion criteria

Presence of any contraindication to CMR examination.
Unwillingness to participate in the study or to provide informed consent.

Treatment and study plan

Primary outcomes

Number of participants with sudden cardiac death

Time frame: 5-year

Secondary outcomes

Number of participants with all-cause mortality

Time frame: 5-year
Number of participants with atrial fibrillation

Time frame: 5-year
Number of participants with heart failure hospitalization

Time frame: 5-year

Sponsors and collaborators

Lead sponsor

Minjie Lu

Other

Registry information

Important dates

Study start: 2010
Primary completion: 2028
Study completion: 2030
First posted: Jan 13, 2026
Registry last updated: Jan 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Not Yet Recruiting